DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp8 and phoA

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_414917.2	Gene:	phoA / 945041	ECOCYCID:	EG10727	Length:	471	Species:	Escherichia coli

Alignment Length:	494	Identity:	129/494 - (26%)
Similarity:	188/494 - (38%)	Gaps:	141/494 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 NSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSF---ERFPYTGLSRTYCSNAQ-- 142
            :.:.|||||:.:||||..|.:.|||        |..|.:...|   :..|.||....|..|.:
E. coli    60 SDKPAKNIILLIGDGMGDSEITAAR--------NYAEGAGGFFKGIDALPLTGQYTHYALNKKTG 116

  Fly   143 ----VPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVT 203
                |.|||.:|||:..||||            ||.............:|.|.|:.||.:||.|:
E. coli   117 KPDYVTDSAASATAWSTGVKT------------YNGALGVDIHEKDHPTILEMAKAAGLATGNVS 169

  Fly   204 TTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANS--CIDMATQ------LVTQTPGKNFEVMF 260
            |..|..|:|:...|...:|  :|      ||..|.|  |...|.:      :..|......:|..
E. coli   170 TAELQDATPAALVAHVTSR--KC------YGPSATSEKCPGNALEKGGKGSITEQLLNARADVTL 226

  Fly   261 GGGMGKFLPNSIVDSHGNPGERSDGVNLLSRWQG--------------LHDGGVL--VTNRNQLL 309
            |||...|...:      ..||          |||              :.|...|  ||..||..
E. coli   227 GGGAKTFAETA------TAGE----------WQGKTLREQAQARGYQLVSDAASLNSVTEANQQK 275

  Fly   310 KLNVSAVSSVIGLFQSKLM---------NFHLEAD------------DTYQPTLSELTEVTIKKL 353
            .|        :|||....|         .:|...|            :...|||:::|:..|:.|
E. coli   276 PL--------LGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELL 332

  Fly   354 SQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDIE-DTLIVVTADHGHAV 417
            |:| |.|:|..:||..||..:|.......:.|.::.::|:|.|.:....| :||::|||||.||.
E. coli   333 SKN-EKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHAS 396

  Fly   418 SIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDENGQRIPLDDILGSDDAITPSYIP 482
            .|.. |....|  |:.|.....:|. ..|::|                     |:.:
E. coli   397 QIVA-PDTKAP--GLTQALNTKDGA-VMVMSY---------------------GNSE-------- 428

  Fly   483 KDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYA 521
            :|...|:|..:.|.|.||.:....|:..|:.:.:.|..|
E. coli   429 EDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAA 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	128/489 (26%)
phoA	NP_414917.2	PRK10518	1..471	CDD:236706	129/494 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
	9	8.960