DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Akp3

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_073171.2	Gene:	Akp3 / 64621	RGDID:	621650	Length:	558	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	204/496 - (41%)
Similarity:	281/496 - (56%)	Gaps:	35/496 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KLKFSTDVATEKYTPPEEMDPQYWYNIADE--EITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVA 104
            :|:.|..|     .|.||.:|.:|...|.:  .:.|:|   ||....|||:|:||||||.:.||.
  Rat    13 RLQLSLSV-----IPVEEENPAFWNQKAADALNVAKKL---QPIQTSAKNLIIFLGDGMGVPTVT 69

  Fly   105 AARILKGQRQGNTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAA 169
            |.||||||.:||.|.|:.|:.:.|||..||:||..:.||||||.||||||||||||...||||||
  Rat    70 ATRILKGQLEGNLGPETPLAMDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAA 134

  Fly   170 VEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYG 234
            ..::.|..:.  .|.:.|:...|:.||||.|:||||.:.||||:|.|..|.||.|..|.|:.:..
  Rat   135 ARFDQCNTTF--GNEVLSVMYRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASA 197

  Fly   235 VDANSCIDMATQLVTQTPGKNFEVMFGGGMGKFLPNSIVDSH-----GNPGERSDGVNLLSRWQG 294
            :. ..|.|:|||||:   ..:..|:.|||.....|....|..     ...|.|.||.||:..|..
  Rat   198 LQ-EGCKDIATQLVS---NMDINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLS 258

  Fly   295 LHDGGVLVTNRNQLLKLNVS-AVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKE 358
            .|.|...|.||.:|::.::. :|:.::|||:.....|.::.|....|:|.::||..:..||:|.:
  Rat   259 KHQGSQYVWNRQELIQKSLDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPK 323

  Fly   359 HGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYP 423
             |::.|:|||.||.|:|...|..||.||:.|:.||:.|..:|..:|||.:|||||.|..|..||.
  Rat   324 -GFYLFVEGGRIDRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYT 387

  Fly   424 GRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDENGQRIPLDDILGSDDAITPSY-----IPK 483
            .|||.|.|:...:. ::|..|:.:.|..||. |:. .|:|..:.|....|    |||     :|.
  Rat   388 LRGTSIFGLAPLNA-LDGKPYTSILYGNGPG-YVG-TGERPNVTDAESHD----PSYQQQAAVPV 445

  Fly   484 DQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYAACI 524
            ....|.||||.|||.|||:||..||.:|:.|.|:||:|.|:
  Rat   446 KSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	190/448 (42%)
Akp3	NP_073171.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9148
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860