DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and AgaP_AGAP011305

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_001688180.1	Gene:	AgaP_AGAP011305 / 5667804	VectorBaseID:	AGAP011305	Length:	571	Species:	Anopheles gambiae

Alignment Length:	545	Identity:	223/545 - (40%)
Similarity:	316/545 - (57%)	Gaps:	59/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQ---AANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEI 73
            :.||:||:.|:|....|  :.....||   .:::..|.:....:|    :|.:.:||..:|...:
Mosquito     9 VFLLIALSATSLSARGE--STPREPGQQHPRSDRRVFQSVPIYDK----QEEESEYWRTVAQRSL 67

  Fly    74 TKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYC 138
            ..:...|: :.:||||::.|:||||.||||||||:..|      .|...||||:|||.||::|||
Mosquito    68 QHQAAHPR-SERKAKNVVYFIGDGMGLSTVAAARMYLG------NENMYLSFEKFPYFGLAKTYC 125

  Fly   139 SNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVT 203
            .|.||.||||||||||.|||.|...:.|:|:|:.::|...:: |.....:.||||.|||:|||||
Mosquito   126 VNRQVADSACTATAYLSGVKINYGMLNVAASVKRSSCEYDRN-ATEFKGLLEWAQQAGKATGIVT 189

  Fly   204 TTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSC---------IDMATQLVTQTPGKNFEVM 259
            ||.:|||:|.|.||.:|:|.||.||:|.      |.|         :|:|||||..:.|||.:|.
Mosquito   190 TTRITHATPGGTYASSADRDWEDDTEVN------NDCPTTRQEDKPVDIATQLVYGSVGKNLKVA 248

  Fly   260 FGGGMGKFLPNSIVDSHGNPGERSDGVNLLSRWQGLH-DGGV--LVTNRNQLLKLNVS-AVSSVI 320
            .|.|...|:|..:.|..|..|:|||||||:..|:.:| |.|.  .|:::..||:...| .:..::
Mosquito   249 LGCGRRHFIPADVKDEDGKAGKRSDGVNLIEAWKEVHADMGEARYVSDKKSLLEAAKSKKLDYLL 313

  Fly   321 GLFQSKLMNFHLEADD----TYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGY 381
            |||.|....::||.||    ..:|.|:::.:..:..| ::.|.||..|:||||||..:|..:...
Mosquito   314 GLFDSSHCLYNLEIDDQKLGDVKPKLTDMVDAALSML-EDSEQGYVLFVEGGLIDTAHHSNRPRL 377

  Fly   382 ALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSV 446
            :|:|..||.|||:|||..|..|||||||::||.|.:...|||.||..||||.. .:|.:|:.|:.
Mosquito   378 SLEETKEFHKAIELARTRTSEEDTLIVVSSDHSHTLMYNGYPTRGNDILGIGD-ISDKDGLPYTT 441

  Fly   447 LNYAAGP---NQYLDEN-GQRIPLDDILGSDDAITPSY-------IPKDQGVHSGEDVGIFASGP 500
            |:||.|.   ..|.|.| .:|:   |:.|.|.:   .|       :|.....|.|||||::||||
Mosquito   442 LSYANGEGFYQTYADGNPSKRL---DVTGYDFS---DYRQRYLATVPLSSETHGGEDVGVYASGP 500

  Fly   501 QSHLFTGVMQQSTIPHLMAYAACIG 525
            .:|||.|..:|:.||.|:||||.||
Mosquito   501 GAHLFGGSTEQNVIPLLIAYAANIG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	203/464 (44%)
AgaP_AGAP011305	XP_001688180.1	PhoA	61..527	CDD:224699	209/487 (43%)
AgaP_AGAP011305	XP_001688180.1	ALP_like	81..525	CDD:304875	203/464 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	5	4.930