DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and alpi.1

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001014375.1	Gene:	alpi.1 / 541539	ZFINID:	ZDB-GENE-050327-78	Length:	532	Species:	Danio rerio

Alignment Length:	524	Identity:	212/524 - (40%)
Similarity:	289/524 - (55%)	Gaps:	51/524 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEITKR 76
            :||||||.....|                     |.|.|.|     .|.||.||.:.|...:...
Zfish    13 LLLLLALVLNTSC---------------------SLDSAAE-----WEKDPAYWNDQARRTLQTA 51

  Fly    77 LQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCSNA 141
            |.||. ...:|||||:|:||||.:|||:|||||:||.:|.:|||:.|:.:.|||..||:|||.:.
Zfish    52 LTLPL-RVNRAKNIILFVGDGMGVSTVSAARILRGQMEGQSGEETILAMDTFPYLALSKTYCVDK 115

  Fly   142 QVPDSACTATAYLCGVKTNIVNIGVSA-AVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTTT 205
            ||.|||.|||||.||||.|...:|:|| ||.| .|..:.  .|.:.|:...|:..|||.||||||
Zfish   116 QVADSASTATAYHCGVKANAKTVGLSAKAVAY-ECNTTF--GNEVFSVLHRAKAQGKSVGIVTTT 177

  Fly   206 TLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGGMGKFLPN 270
            .:.||||:.|||.:.:|.|..|.||.| ......|.|:||||||.|   :.:|:.|||.....|.
Zfish   178 RVQHASPAAAYAHSVSRKWYSDADVPS-EARRQGCKDIATQLVTNT---DIDVILGGGRMYMTPK 238

  Fly   271 SIVD----SHGNPGERSDGVNLLSRWQGLHDG--GVLVTNRNQLLKLNVSAVSSVIGLFQSKLMN 329
            ...|    |..:.|:|.|..||::.|.....|  ...|.|:.|...::|.....::|||:.|.|.
Zfish   239 GTPDPEYSSSSHKGDRKDKKNLINVWLNARKGRNAQYVWNKEQFNAVDVKTTDCLMGLFEPKDMR 303

  Fly   330 FHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQ 394
            |.:..:.|..|::.::||..|:.||:|.: |:|.|:|||.||:|:|...|..||.|.:.|::|||
Zfish   304 FEVFRNRTRDPSIVDMTEKAIQILSKNPK-GFFLFVEGGRIDHGHHDGVAKLALTETIMFDRAIQ 367

  Fly   395 LARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGI--NQHDTDINGVQYSVLNYAAGPNQYL 457
            .|.::|...|||.||||||.|..:..|...||.||.|:  .|.:.|:   .|:.:.||.||. |.
Zfish   368 RASELTSESDTLTVVTADHSHVFTFGGKTPRGNPIFGLAPKQAEDDL---PYTSILYANGPG-YD 428

  Fly   458 DENGQR--IPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAY 520
            ..||.|  :.:.|.. .::....:.:|.:...|.||||.|:|.||.:|||.||.:|:.:.|.|||
Zfish   429 HVNGTRGNVSVLDYY-DEEYKQQAAVPLESETHGGEDVAIYAKGPMAHLFHGVKEQNYVAHAMAY 492

  Fly   521 AACI 524
            |||:
Zfish   493 AACL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	191/448 (43%)
alpi.1	NP_001014375.1	PhoA	46..493	CDD:224699	191/460 (42%)
alpi.1	NP_001014375.1	Alk_phosphatase	61..496	CDD:278666	191/447 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593240
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860