DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Alp5

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_650931.1	Gene:	Alp5 / 42482	FlyBaseID:	FBgn0038845	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	215/478 - (44%)
Similarity:	293/478 - (61%)	Gaps:	28/478 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YWYNIADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERF 128
            ||.....:.:.::| ..:||.::|||:|:||||||.::|.:|||.|.|      |||.|||||.|
  Fly    62 YWRQQGVQFVQQKL-ASEPNKRQAKNVILFLGDGMGVTTTSAARNLLG------GEEKSLSFENF 119

  Fly   129 PYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQ 193
            |:||||:||..:..||||||||||||||||.....|||:..|...:|....|.:..:.|||:||.
  Fly   120 PFTGLSKTYSVDKIVPDSACTATAYLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIAKWAM 184

  Fly   194 NAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDV-TSYGVDANSCI-DMATQLVTQTPGKNF 256
            .|||..|:||||.:|||||||.||..|.|.||.|.:| |..|  |.|.| |:|.||.....|...
  Fly   185 EAGKWAGLVTTTRVTHASPSGVYAHIAERDWENDAEVATDCG--AGSGINDIAYQLARGEVGSKL 247

  Fly   257 EVMFGGGMGKFLPNSIVDSHGNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNVSAVSSVIG 321
            :|:.|||...|:.:|:    .:.|:|:||:||:..::...:..|.||...:|..::|:....::|
  Fly   248 KVIMGGGRKHFVDSSL----ESWGKRTDGLNLIDEFKSASENNVYVTTAAELAAVDVTKTDRLLG 308

  Fly   322 LFQSKLMNFHLE-ADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDE 385
            ||....:.:.:| ..::.||||.::|...|:.:||| |.|||.|||||.||..:|..:|..||:|
  Fly   309 LFNDDHLQYLMETTTESSQPTLEQMTRKAIEYMSQN-EQGYFLFIEGGRIDQAHHINQARMALNE 372

  Fly   386 ALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILG---INQHDTDINGVQYSVL 447
            .:||.|||..|:::|..:|||:||||||.|..:.|||..||:.:.|   :|.||    |..|.||
  Fly   373 TIEFSKAIAAAQELTSEDDTLLVVTADHSHVFTYAGYSYRGSDVFGKTPVNGHD----GKPYMVL 433

  Fly   448 NYAAGP---NQYLDENGQR-IPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGV 508
            :||.||   |.|..|..:| .|...:.|..|...||.:|.|...|.|:||.::|.||.:||||||
  Fly   434 SYANGPSYENFYDAETMERKDPTTVVKGDHDDEFPSGVPIDMDSHGGDDVPVYALGPWAHLFTGV 498

  Fly   509 MQQSTIPHLMAYAACIGSGKQVC 531
            .:||||||:||||:|:|.|..:|
  Fly   499 YEQSTIPHMMAYASCLGDGHTMC 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	206/446 (46%)
Alp5	NP_650931.1	Alk_phosphatase	84..514	CDD:278666	206/446 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466659
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900