DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and alpl

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_957301.2	Gene:	alpl / 393982	ZFINID:	ZDB-GENE-040420-1	Length:	561	Species:	Danio rerio

Alignment Length:	539	Identity:	220/539 - (40%)
Similarity:	301/539 - (55%)	Gaps:	44/539 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QRQLV---LPILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWY 66
            :|:|:   :.::.||.|:    |          |..:...|::|          |.:|..|.||.
Zfish    27 KRRLIDNKMKVVQLLILS----C----------LVWEGKTKVQF----------PEQEKRPDYWR 67

  Fly    67 NIADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYT 131
            :.|...:...|:|.:.|...|||||:||||||.:.||.||||||||..|..|||:.|..::||:.
Zfish    68 DFAQRSLKDALKLQELNKNIAKNIILFLGDGMGVPTVTAARILKGQLSGQNGEETQLEMDKFPHV 132

  Fly   132 GLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAG 196
            .||:||.:||||||||.||||:|||||.|...:|||||...:.|..:|  .|.:|||.:||::||
Zfish   133 ALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVRSQCNTTQ--GNEVTSILKWAKDAG 195

  Fly   197 KSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFG 261
            ||.||||||.:.||:||.|||...:|.|..|.|:.:..:. :.|.|:|.||....|..|  |:.|
Zfish   196 KSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEALQ-SGCKDIARQLFENIPDIN--VIMG 257

  Fly   262 GGMGKFLPNSIVDSHGNPGE------RSDGVNLLSRW--QGLHDGGVLVTNRNQLLKLNVSAVSS 318
            ||.....|.:..|.. .||:      |.||.||:..|  :.....|..|.|:..||.||.:.|..
Zfish   258 GGRRSMYPKNTPDVE-YPGDKKQNGTRKDGRNLVGEWIDRVKEKRGFYVWNKKDLLSLNPNNVDY 321

  Fly   319 VIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYAL 383
            ::|||:...:|:.||.:....|:|:|:.:|.||.|.:| |.|:|..:|||.||:|:|..||..||
Zfish   322 LLGLFEPADLNYELERNTENDPSLTEMVDVAIKILKKN-ERGFFLLVEGGRIDHGHHEGKAKQAL 385

  Fly   384 DEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLN 448
            .||:|.::||..|..:|...|||.||||||.|..|..||..||..|.|:....:|::...::.:.
Zfish   386 HEAVEMDRAITRAGLLTSEYDTLTVVTADHSHVFSFGGYTPRGNSIFGLAPTLSDVDQKPFTAIL 450

  Fly   449 YAAGPNQYLDENGQRIPLDDI-LGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQS 512
            |..||...| .||.|..:..: ...::....|.:|.....|.||||.||:.||.:||..||.:|.
Zfish   451 YGNGPGFKL-VNGARENVSTVDYQQNNYQAQSAVPLRMETHGGEDVAIFSKGPMAHLLHGVQEQH 514

  Fly   513 TIPHLMAYAACIGSGKQVC 531
            .|||:||||||||..|..|
Zfish   515 YIPHVMAYAACIGQNKDHC 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	197/445 (44%)
alpl	NP_957301.2	Alk_phosphatase	88..526	CDD:278666	197/445 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593266
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760