DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Alp7

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	340/534 - (63%)
Similarity:	420/534 - (78%)	Gaps:	14/534 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLLALAGTALCG---VQEVHNVLELTGQAANKLKF-------STDVATEKYTPPEEMDPQYWYN 67
            |:|..|..|:|..   :.|:||..:|.|.:.:..|.       ...:|..|..|.||.:.|:||:
  Fly     9 LVLCTLVATSLAASIDMPEIHNQFQLVGGSVSTAKTREGNLIDPNAMAKGKPGPEEEKNAQFWYD 73

  Fly    68 IADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTG 132
            :|.|||.|||:.||.:.:||||:|:||||||.|||||||||.|||.:||||||.|||||:|||||
  Fly    74 LAYEEIAKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTGEEDSLSFEKFPYTG 138

  Fly   133 LSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGK 197
            ||||||||||||||||||||||||||||||.:|::|||.:|||:.|:||||::.|||.|||.|||
  Fly   139 LSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPANQVDSIAAWAQAAGK 203

  Fly   198 STGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDAN---SCIDMATQLVTQTPGKNFEVM 259
            :|||||||||||||||||||||.||.:|.|||:.:||...|   :|.|:||||:||.|||||:||
  Fly   204 ATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYGEGQNDPATCTDIATQLITQAPGKNFDVM 268

  Fly   260 FGGGMGKFLPNSIVDSHGNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNVSAVSSVIGLFQ 324
            .|||:||||||:|.|.....|||||||||||||||||.||||..||||||.:|||.::::||.|:
  Fly   269 LGGGIGKFLPNTITDPFNKKGERSDGVNLLSRWQGLHPGGVLAYNRNQLLSVNVSKITNLIGTFR 333

  Fly   325 SKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEF 389
            |.:|:|:..||...:|||:|:|...|:.:|: ::.|||.|:||||||||||:....|:|.|.|:|
  Fly   334 SGVMSFNKMADPKEEPTLAEMTRKAIEVVSK-RDGGYFLFVEGGLIDYGNHFNSPTYSLSETLQF 397

  Fly   390 EKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPN 454
            |:|:|.|.|:||.|:||||||:||.|.::|:|||||||||||:||.|||:|||:|:.||||.|.|
  Fly   398 EQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPILGLNQDDTDVNGVKYATLNYAVGTN 462

  Fly   455 QYLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMA 519
            |||||:||||.|.|.:|::|.|.||||....|||:|:||||||:|||||||||||||||||||||
  Fly   463 QYLDEHGQRIDLTDQIGAEDFIHPSYIHGTIGVHAGDDVGIFATGPQSHLFTGVMQQSTIPHLMA 527

  Fly   520 YAACIGSGKQVCDN 533
            ||:|||:|..:|||
  Fly   528 YASCIGNGPTLCDN 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	304/439 (69%)
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	304/439 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466635
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	1	1.000	-	-		H129600
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.900