DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Alpl

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_037191.2	Gene:	Alpl / 25586	RGDID:	2100	Length:	524	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	219/533 - (41%)
Similarity:	303/533 - (56%)	Gaps:	45/533 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLPILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEE 72
            ::||.|:|  ..||.|                           |..:.|.:|.||.||...|.|.
  Rat     1 MILPFLVL--AIGTCL---------------------------TNSFVPEKEKDPSYWRQQAQET 36

  Fly    73 ITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTY 137
            :...|:|.:.|:..||||||||||||.:|||.||||||||...|||||:.|..::||:..||:||
  Rat    37 LKNALKLQKLNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTY 101

  Fly   138 CSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIV 202
            .:||||||||.||||||||||.|...:|||||.|...|..:|  .|.:|||..||::||||.|||
  Rat   102 NTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQ--GNEVTSILRWAKDAGKSVGIV 164

  Fly   203 TTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGGMGKF 267
            |||.:.||:||.|||.:|:|.|..|.::....: :..|.|:|.||:...  |:.:|:.|||....
  Rat   165 TTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL-SQGCKDIAYQLMHNI--KDIDVIMGGGRKYM 226

  Fly   268 LPNSIVD-----SHGNPGERSDGVNLLSRWQGL---HDGGVLVTNRNQLLKLNVSAVSSVIGLFQ 324
            .|.:..|     .....|.|.||::|:|.|:..   |.....|.||.:||.|:.|.|..::|||:
  Rat   227 YPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFE 291

  Fly   325 SKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEF 389
            ...|.:.|..::...|:|||:.||.::.|::|.: |:|..:|||.||:|:|..||..||.||:|.
  Rat   292 PGDMQYELNRNNLTDPSLSEMVEVALRILTKNPK-GFFLLVEGGRIDHGHHEGKAKQALHEAVEM 355

  Fly   390 EKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPN 454
            ::||..|..||..:|||.||||||.|..:..||..||..|.|:....:|.:...::.:.|..||.
  Rat   356 DEAIGKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG 420

  Fly   455 -QYLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLM 518
             :.:|...:.:.:.| ...::....|.:|.....|.||||.:||.||.:||..||.:|:.|||:|
  Rat   421 YKVVDGERENVSMVD-YAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVM 484

  Fly   519 AYAACIGSGKQVC 531
            |||:|||:....|
  Rat   485 AYASCIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	196/445 (44%)
Alpl	NP_037191.2	Alk_phosphatase	51..490	CDD:395188	196/445 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9148
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760