Protein Alignment Alp8 and ALPG

DIOPT Version :9

• Sequence 1: NP_001286709.1
• Gene: Alp8 / 37540
• FlyBaseID: FBgn0034712
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_112603.2
• Gene: ALPG / 251
• HGNCID: 441
• Length: 532
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 212/524 - (40%)
• Similarity: 291/524 - (55%)
• Gaps: 53/524 - (10%)

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEI--T 74
            :||||.|                       :|:.|..:     .|.||.:|.:|...|.|.:  .
Human     6 VLLLLGL-----------------------RLQLSLGI-----IPVEEENPDFWNRQAAEALGAA 42

  Fly    75 KRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCS 139
            |:|   ||....|||:|:||||||.:|||.||||||||::...|.|:.|:.:||||..||:||..
Human    43 KKL---QPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSV 104

  Fly   140 NAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTT 204
            :..||||..||||||||||.|...||:|||..:|.|..::  .|.:.|:...|:.||||.|:|||
Human   105 DKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVTT 167

  Fly   205 TTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGGMGKFLP 269
            |.:.||||:||||.|.||.|..|.||.: ......|.|:||||::   ..:.:|:.|||.....|
Human   168 TRVQHASPAGAYAHTVNRNWYSDADVPA-SARQEGCQDIATQLIS---NMDIDVILGGGRKYMFP 228

  Fly   270 -----NSIVDSHGNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNVS-AVSSVIGLFQSKLM 328
                 ....|.:...|.|.||.||:..|...|.|...|.||.:||:.::. :|:.::|||:...|
Human   229 MGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDM 293

  Fly   329 NFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAI 393
            .:.:..|.|..|:|.|:||..:..||:| ..|:|.|:|||.||:|:|.::|..||.|.:.|:.||
Human   294 KYEIHRDSTLDPSLMEMTEAALLLLSRN-PRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI 357

  Fly   394 QLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGI---NQHDTDINGVQYSVLNYAAGPNQ 455
            :.|..:|..||||.:|||||.|..|..|||.||:.|.|:   ...|..    .|:||.|..||..
Human   358 ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRK----AYTVLLYGNGPGY 418

  Fly   456 YLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAY 520
            .|.:..:....:...||.:....|.:|.|...|:||||.:||.|||:||..||.:|:.|.|:||:
Human   419 VLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAF 483

  Fly   521 AACI 524
            |||:
Human   484 AACL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	193/446 (43%)
ALPG	NP_112603.2	PRK10518	25..475	CDD:236706	195/463 (42%)
		Alk_phosphatase	52..487	CDD:278666	193/445 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..443		2/20 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129600
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760