Protein Alignment Alp8 and ALPG

DIOPT Version :10

• Sequence 1: NP_611655.1
• Gene: Alp8 / 37540
• FlyBaseID: FBgn0034712
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_112603.2
• Gene: ALPG / 251
• HGNCID: 441
• Length: 532
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 212/524 - (40%)
• Similarity: 291/524 - (55%)
• Gaps: 53/524 - (10%)

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEI--T 74
            :||||.|                       :|:.|..:     .|.||.:|.:|...|.|.:  .
Human     6 VLLLLGL-----------------------RLQLSLGI-----IPVEEENPDFWNRQAAEALGAA 42

  Fly    75 KRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCS 139
            |:|   ||....|||:|:||||||.:|||.||||||||::...|.|:.|:.:||||..||:||..
Human    43 KKL---QPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSV 104

  Fly   140 NAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTT 204
            :..||||..||||||||||.|...||:|||..:|.|..::  .|.:.|:...|:.||||.|:|||
Human   105 DKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVTT 167

  Fly   205 TTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGGMGKFLP 269
            |.:.||||:||||.|.||.|..|.||.: ......|.|:||||::   ..:.:|:.|||.....|
Human   168 TRVQHASPAGAYAHTVNRNWYSDADVPA-SARQEGCQDIATQLIS---NMDIDVILGGGRKYMFP 228

  Fly   270 -----NSIVDSHGNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNVS-AVSSVIGLFQSKLM 328
                 ....|.:...|.|.||.||:..|...|.|...|.||.:||:.::. :|:.::|||:...|
Human   229 MGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDM 293

  Fly   329 NFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAI 393
            .:.:..|.|..|:|.|:||..:..||:| ..|:|.|:|||.||:|:|.::|..||.|.:.|:.||
Human   294 KYEIHRDSTLDPSLMEMTEAALLLLSRN-PRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI 357

  Fly   394 QLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGI---NQHDTDINGVQYSVLNYAAGPNQ 455
            :.|..:|..||||.:|||||.|..|..|||.||:.|.|:   ...|..    .|:||.|..||..
Human   358 ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRK----AYTVLLYGNGPGY 418

  Fly   456 YLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAY 520
            .|.:..:....:...||.:....|.:|.|...|:||||.:||.|||:||..||.:|:.|.|:||:
Human   419 VLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAF 483

  Fly   521 AACI 524
            |||:
Human   484 AACL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_611655.1	ALP_like	88..525	CDD:474031	193/446 (43%)
ALPG	NP_112603.2	Alk_phosphatase	52..487	CDD:395188	193/445 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..443		2/20 (10%)