Protein Alignment Alp8 and ALPP

DIOPT Version :9

• Sequence 1: NP_001286709.1
• Gene: Alp8 / 37540
• FlyBaseID: FBgn0034712
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001623.3
• Gene: ALPP / 250
• HGNCID: 439
• Length: 535
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 213/526 - (40%)
• Similarity: 295/526 - (56%)
• Gaps: 51/526 - (9%)

  Fly    11 PILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEI-- 73
            |.:|||.|    |.|:               :|:.|..:     .|.||.:|.:|...|.|.:
Human     4 PCMLLLLL----LLGL---------------RLQLSLGI-----IPVEEENPDFWNREAAEALGA 44

  Fly    74 TKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYC 138
            .|:|   ||....|||:|:||||||.:|||.||||||||::...|.|..|:.:||||..||:||.
Human    45 AKKL---QPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYN 106

  Fly   139 SNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVT 203
            .:..||||..||||||||||.|...||:|||..:|.|..::  .|.:.|:...|:.||||.|:||
Human   107 VDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVT 169

  Fly   204 TTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGG----- 263
            ||.:.||||:|.||.|.||.|..|.||.: ......|.|:||||::   ..:.:|:.|||
Human   170 TTRVQHASPAGTYAHTVNRNWYSDADVPA-SARQEGCQDIATQLIS---NMDIDVILGGGRKYMF 230

  Fly   264 -MGKFLPNSIVDSHGNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNVS-AVSSVIGLFQSK 326
             ||...| ...|.:...|.|.||.||:..|.....|...|.||.:|::.::. :|:.::|||:..
Human   231 RMGTPDP-EYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPG 294

  Fly   327 LMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEK 391
            .|.:.:..|.|..|:|.|:||..::.||:| ..|:|.|:|||.||:|:|.::|..||.|.:.|:.
Human   295 DMKYEIHRDSTLDPSLMEMTEAALRLLSRN-PRGFFLFVEGGRIDHGHHESRAYRALTETIMFDD 358

  Fly   392 AIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGI---NQHDTDINGVQYSVLNYAAGP 453
            ||:.|..:|..||||.:|||||.|..|..|||.||:.|.|:   ...|..    .|:||.|..||
Human   359 AIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRK----AYTVLLYGNGP 419

  Fly   454 NQYLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLM 518
            ...|.:..:....:...||.:....|.:|.|:..|:||||.:||.|||:||..||.:|:.|.|:|
Human   420 GYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVM 484

  Fly   519 AYAACI 524
            |:|||:
Human   485 AFAACL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	192/447 (43%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	194/464 (42%)
		Alk_phosphatase	55..490	CDD:278666	192/446 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..449		3/23 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760