Protein Alignment Alp8 and ALPL

DIOPT Version :9

• Sequence 1: NP_001286709.1
• Gene: Alp8 / 37540
• FlyBaseID: FBgn0034712
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_000469.3
• Gene: ALPL / 249
• HGNCID: 438
• Length: 524
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 206/491 - (41%)
• Similarity: 290/491 - (59%)
• Gaps: 18/491 - (3%)

  Fly    51 TEKYTPPEEMDPQYWYNIADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQG 115
            |....|.:|.||:||.:.|.|.:...|:|.:.|:..|||:||||||||.:|||.||||||||...
Human    15 TNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHH 79

  Fly   116 NTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQD 180
            |.|||:.|..::||:..||:||.:||||||||.||||||||||.|...:|||||.|.:.|..:|
Human    80 NPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ- 143

  Fly   181 PANRLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMAT 245
             .|.:|||..||::||||.||||||.:.||:||.|||.:|:|.|..|.::....: :..|.|:|.
Human   144 -GNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL-SQGCKDIAY 206

  Fly   246 QLVTQTPGKNFEVMFGGGMGKFLPNSIVD-----SHGNPGERSDGVNLLSRWQGL---HDGGVLV 302
            ||:...  ::.:|:.|||.....|.:..|     .....|.|.||::|:..|:..   :.....:
Human   207 QLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFI 269

  Fly   303 TNRNQLLKLNVSAVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEG 367
            .||.:||.|:...|..::|||:...|.:.|..::...|:|||:..|.|:.|.:|.: |:|..:||
Human   270 WNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPK-GFFLLVEG 333

  Fly   368 GLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGI 432
            |.||:|:|..||..||.||:|.::||..|..:|..||||.||||||.|..:..||..||..|.|:
Human   334 GRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGL 398

  Fly   433 NQHDTDINGVQYSVLNYAAGPNQYLDENGQR--IPLDDILGSDDAITPSYIPKDQGVHSGEDVGI 495
            ....:|.:...::.:.|..||. |....|:|  :.:.| ...::....|.:|.....|.||||.:
Human   399 APMLSDTDKKPFTAILYGNGPG-YKVVGGERENVSMVD-YAHNNYQAQSAVPLRHETHGGEDVAV 461

  Fly   496 FASGPQSHLFTGVMQQSTIPHLMAYAACIGSGKQVC 531
            |:.||.:||..||.:|:.:||:||||||||:....|
Human   462 FSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHC 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	190/446 (43%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:333956	190/446 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760