DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and ALPI

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001622.2	Gene:	ALPI / 248	HGNCID:	437	Length:	528	Species:	Homo sapiens

Alignment Length:	521	Identity:	209/521 - (40%)
Similarity:	292/521 - (56%)	Gaps:	47/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEITKR 76
            :||||.|                       :|:.|..|     .|.||.:|.:|...|.|.:...
Human     6 VLLLLGL-----------------------RLQLSLGV-----IPAEEENPAFWNRQAAEALDAA 42

  Fly    77 LQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCSNA 141
            .:| ||..:.|||:|:|||||:.:.||.|.||||||:.|..|.|:.|:.:||||..||:||..:.
Human    43 KKL-QPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDR 106

  Fly   142 QVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTTTT 206
            ||||||.||||||||||.|...||:|||..:|.|..::  .|.:.|:...|:.||||.|:||||.
Human   107 QVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKQAGKSVGVVTTTR 169

  Fly   207 LTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGG------MG 265
            :.||||:|.||.|.||.|..|.|:.: ......|.|:||||::   ..:.:|:.|||      ||
Human   170 VQHASPAGTYAHTVNRNWYSDADMPA-SARQEGCQDIATQLIS---NMDIDVILGGGRKYMFPMG 230

  Fly   266 KFLPNSIVDSHGNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLLKLNV-SAVSSVIGLFQSKLMN 329
            ...|....|:..| |.|.||.||:..|...|.|...|.||.:|::.:: .:|:.::|||:.....
Human   231 TPDPEYPADASQN-GIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTK 294

  Fly   330 FHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQ 394
            :.:..|.|..|:|.|:||..::.||:| ..|::.|:|||.||:|:|...|..||.||:.|:.||:
Human   295 YEIHRDPTLDPSLMEMTEAALRLLSRN-PRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIE 358

  Fly   395 LARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDE 459
            .|..:|..||||.:|||||.|..|..||..||:.|.|:.......:....|:| |..||. |:..
Human   359 RAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSIL-YGNGPG-YVFN 421

  Fly   460 NGQRIPLDDI-LGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLMAYAAC 523
            :|.|..:::. .||.|....:.:|.....|.||||.:||.|||:||..||.:||.:.|:||:|||
Human   422 SGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAAC 486

  Fly   524 I 524
            :
Human   487 L 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	190/445 (43%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	190/444 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760