DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Alpi

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_073156.3	Gene:	Alpi / 24197	RGDID:	2099	Length:	540	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	201/482 - (41%)
Similarity:	282/482 - (58%)	Gaps:	29/482 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PPEEMDPQYWYNIADE--EITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTG 118
            |.||.:|.:|...|.|  ::.|:|   ||....|||:|:||||||.:.||.|.||||||..|:.|
  Rat    23 PVEEENPVFWNQKAKEALDVAKKL---QPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLG 84

  Fly   119 EESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPAN 183
            .|:.|:.:.||:|.||:||..:.||||||.||||||||||.|...||||||..:|.|.::.  .|
  Rat    85 PETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTF--GN 147

  Fly   184 RLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLV 248
            .:.|:...|:.||||.|:||||.:.||||:|.||.|.||.|..|.|:.|..:. ..|.|:||||:
  Rat   148 EVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQ-EGCKDIATQLI 211

  Fly   249 TQTPGKNFEVMFGGGMGKFLPNSIVDSHGNPGE------RSDGVNLLSRWQGLHDGGVLVTNRNQ 307
            :   ..:.:|:.|||.....|....|.. .||:      |.|..||:..|...:.|...|.||.|
  Rat   212 S---NMDIDVILGGGRKFMFPKGTPDPE-YPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQ 272

  Fly   308 LLKLNVS-AVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLID 371
            |::.:.. ||:.::|||:...|.:.:..:.:..|:|:|:|||.::.||:|.: |::.|:|||.||
  Rat   273 LMQASQDPAVTRLMGLFEPAEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQ-GFYLFVEGGRID 336

  Fly   372 YGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILG---IN 433
            .|:|...|..||.||:.|:.||:.|..:|:.:|||.::||||.|..:..||..|||.|.|   :|
  Rat   337 QGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLN 401

  Fly   434 QHDTDINGVQYSVLNYAAGPNQYLDENGQRIPLDDILGSD-DAITPSYIPKDQGVHSGEDVGIFA 497
            ..|    |..|:.:.|..||. |:..:|.|..:.|....| :....:.:|.....|.||||.|||
  Rat   402 AQD----GKSYTSILYGNGPG-YVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFA 461

  Fly   498 SGPQSHLFTGVMQQSTIPHLMAYAACI 524
            .|||:||..||.:|:.|.|:||:|.|:
  Rat   462 RGPQAHLVHGVQEQNYIAHVMAFAGCL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	189/448 (42%)
Alpi	NP_073156.3	Alk_phosphatase	53..488	CDD:278666	189/447 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9148
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760