DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and AgaP_AGAP001684

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_321411.3	Gene:	AgaP_AGAP001684 / 1281493	VectorBaseID:	AGAP001684	Length:	548	Species:	Anopheles gambiae

Alignment Length:	548	Identity:	234/548 - (42%)
Similarity:	322/548 - (58%)	Gaps:	38/548 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQAANKLKF---------STDVATE---------KYTP-- 56
            :.:.|||.| .|.....:|:..|......:..:|         |||...:         ::.|
Mosquito     6 LCVYLALVG-GLVSTSPLHHEAEEEYDPMHPQRFLFADLAPTASTDQRAKRSSASMPKLRFEPPS 69

  Fly    57 PEEMDPQYWYNIADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEES 121
            |.|...|||.|:|.:.:.::|...:.|.:.|||:|||||||:.:.|:||.|:..|.      |.:
Mosquito    70 PNEQHAQYWNNVAQDILDRQLHKNRLNRKVAKNVIMFLGDGLSIPTLAATRVYLGD------EST 128

  Fly   122 SLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLT 186
            .||||||||.|||:|||:|.||.||||||||||.|||.|...||::||....:|.|..|.:|.:.
Mosquito   129 ELSFERFPYVGLSKTYCANVQVADSACTATAYLAGVKANYGTIGLTAAAALGDCQAQNDTSNHVH 193

  Fly   187 SIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQT 251
            |||:|||:||.|||.||||.:|:|||:|.||.||||.||.:..:...|.|...|.|:|:||:...
Mosquito   194 SIAKWAQDAGLSTGFVTTTEVTNASPAGMYAHTANRNWEYNGAIEKDGFDPAVCQDIASQLIHGE 258

  Fly   252 PGKNFEVMFGGGMGKFLPNSIVDSHGNPGERSDGVNLLSRWQ--GLHDGGVLVTNRNQLLKLNVS 314
            .||:..|:.|||..:|||....|..|..|.|:||.:|:..||  ..|.....|.||.|||:.|.:
Mosquito   259 VGKHMRVIMGGGRREFLPTHETDIDGIRGRRTDGEDLIKHWQHHHSHHRSAYVQNRVQLLETNTA 323

  Fly   315 --AVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYT 377
              ....::|||.||.:.:||:||:...|||||:....:..|.:| ::|||.|:|||.||:|:|||
Mosquito   324 HGETDYLLGLFSSKHLPYHLDADEQQIPTLSEMVSTAMDILERN-DNGYFLFVEGGRIDHGHHYT 387

  Fly   378 KAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGV 442
            :...|.||.:||.|||::||..|..::|||||||||.|.::::||..|...|||:|......:.:
Mosquito   388 QPIRAFDETVEFAKAIEMARSRTSQDNTLIVVTADHSHTMTMSGYSSRKNDILGVNNGQRADDEL 452

  Fly   443 QYSVLNYAAGPNQYLDENGQ---RIPLDDILGSDDAIT-PSYIPKDQGVHSGEDVGIFASGPQSH 503
            .|:.::||.||.  .|.|.|   |:.|:.:...|.:.. ||.:|.....|.|:||.:|||||.:|
Mosquito   453 PYATISYANGPG--YDRNVQREARLDLNRVDMRDKSFAFPSTVPLGLETHGGDDVAVFASGPWAH 515

  Fly   504 LFTGVMQQSTIPHLMAYAACIGSGKQVC 531
            ||:|..:|..|||.||||.|||.|:..|
Mosquito   516 LFSGTYEQHFIPHAMAYAGCIGPGRTAC 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	208/444 (47%)
AgaP_AGAP001684	XP_321411.3	ALP_like	101..537	CDD:304875	208/444 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	6	5.830