DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Akp3

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	526	Identity:	211/526 - (40%)
Similarity:	285/526 - (54%)	Gaps:	58/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTPPEEMDPQYWYNIADEEITKR 76
            :||||.|                       :|:.|..|     .|.||.:|.:|...|.|.:...
Mouse     6 VLLLLGL-----------------------RLQLSLSV-----IPVEEENPAFWNKKAAEALDAA 42

  Fly    77 LQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGLSRTYCSNA 141
            .:| ||....|||:|:||||||.:.||.|.||||||.:|:.|.|:.|:.:||||..||:||..:.
Mouse    43 KKL-QPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPLAMDRFPYMALSKTYSVDR 106

  Fly   142 QVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTTTT 206
            ||||||.||||||||||||...||||||..::.|..:.  .|.:.|:...|:.||||.|:||||.
Mouse   107 QVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTF--GNEVFSVMYRAKKAGKSVGVVTTTR 169

  Fly   207 LTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGGMGKFLPNS 271
            :.||||||.|..|.||.|..|.|:.:..: ...|.|:||||::   ..:..|:.|||.....|..
Mouse   170 VQHASPSGTYVHTVNRNWYGDADMPASAL-REGCKDIATQLIS---NMDINVILGGGRKYMFPAG 230

  Fly   272 IVDSH-----GNPGERSDGVNLLSRWQGLHDGGVLVTNRNQLL-KLNVSAVSSVIGLFQSKLMNF 330
            ..|..     ...|.|.||.||:..|...|.|...|.||.||: |....:|:.::|||:.....|
Mouse   231 TPDPEYPNDANETGTRLDGRNLVQEWLSKHQGSQYVWNREQLIQKAQDPSVTYLMGLFEPVDTKF 295

  Fly   331 HLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQL 395
            .::.|....|:|.::||..:|.||:|.: |::.|:|||.||.|:|...|..||.||:.|:.||:.
Mouse   296 DIQRDPLMDPSLKDMTEAAVKVLSRNPK-GFYLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIER 359

  Fly   396 ARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQYSVLNYAAGPNQYLDEN 460
            |..:|...|||.:|||||.|..|..||..|||.|.|:...:. ::|..|:.:.|..||. |:. .
Mouse   360 ASQLTSERDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLNA-LDGKPYTSILYGNGPG-YVG-T 421

  Fly   461 GQR--IPLDDILGSDDAITPSY-----IPKDQGVHSGEDVGIFASGPQSHLFTGVMQQSTIPHLM 518
            |:|  :...:..||      ||     :|.....|.||||.|||.|||:||..||.:|:.|.|:|
Mouse   422 GERPNVTAAESSGS------SYRQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVM 480

  Fly   519 AYAACI 524
            |:|.|:
Mouse   481 AFAGCL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	192/450 (43%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	192/449 (43%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760