DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Alpl

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001274101.1	Gene:	Alpl / 11647	MGIID:	87983	Length:	524	Species:	Mus musculus

Alignment Length:	490	Identity:	211/490 - (43%)
Similarity:	293/490 - (59%)	Gaps:	16/490 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TEKYTPPEEMDPQYWYNIADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQG 115
            |..:.|.:|.||.||...|.|.:...|:|.:.|:..|||:||||||||.:|||.||||||||...
Mouse    15 TNSFVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHH 79

  Fly   116 NTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQD 180
            |||||:.|..::||:..||:||.:||||||||.||||||||||.|...:|||||.|...|..:|
Mouse    80 NTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQ- 143

  Fly   181 PANRLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMAT 245
             .|.:|||..||::||||.||||||.:.||:||.|||.:|:|.|..|.::....: :..|.|:|.
Mouse   144 -GNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL-SQGCKDIAY 206

  Fly   246 QLVTQTPGKNFEVMFGGGMGKFLPNSIVD-----SHGNPGERSDGVNLLSRWQGL---HDGGVLV 302
            ||:...  |:.:|:.|||.....|.:..|     .....|.|.||::|:|.|:..   |.....|
Mouse   207 QLMHNI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYV 269

  Fly   303 TNRNQLLKLNVSAVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEG 367
            .||.:||.|:.|.|..::|||:...|.:.|..::...|:|||:.||.::.|::|.: |:|..:||
Mouse   270 WNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLK-GFFLLVEG 333

  Fly   368 GLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGI 432
            |.||:|:|..||..||.||:|.::||..|..||..:|||.||||||.|..:..||..||..|.|:
Mouse   334 GRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGL 398

  Fly   433 NQHDTDINGVQYSVLNYAAGPN-QYLDENGQRIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIF 496
            ....:|.:...::.:.|..||. :.:|...:.:.:.| ...::....|.:|.....|.||||.:|
Mouse   399 APMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVD-YAHNNYQAQSAVPLRHETHGGEDVAVF 462

  Fly   497 ASGPQSHLFTGVMQQSTIPHLMAYAACIGSGKQVC 531
            |.||.:||..||.:|:.|||:||||:|||:....|
Mouse   463 AKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	195/445 (44%)
Alpl	NP_001274101.1	Alk_phosphatase	51..490	CDD:333956	195/445 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760