DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp8 and Alpp

DIOPT Version :9

Sequence 1:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	196/482 - (40%)
Similarity:	287/482 - (59%)	Gaps:	29/482 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PPEEMDPQYWYNIADE--EITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTG 118
            |.||.:|.:|...|.|  |..|:|   ||....|.|:|:.:||||.:|||.|.||||||:||:.|
  Rat    21 PVEEENPAFWNRKAAEALEAAKKL---QPIQTSANNLIILMGDGMGVSTVTATRILKGQQQGHLG 82

  Fly   119 EESSLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPAN 183
            .|:.|:.:|||:..||:||.::.||||||.|.||:|||||||:..||:|||..:|.|..:.  .|
  Rat    83 PETPLAMDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTW--GN 145

  Fly   184 RLTSIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLV 248
            .:.|:...|:.||||.|:||||::.||||:|.||.|.||.|..|..:::..:. ..|.|:|.||:
  Rat   146 EVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAHMSTAALQ-EGCKDIAMQLI 209

  Fly   249 TQTPGKNFEVMFGGGMGKFLPNSIVDSH-----GNPGERSDGVNLLSRWQGLHDGGVLVTNRNQL 308
            :.|   :.:|:.|||.....|....|..     ...|.|.||.||:..|...|.|...|.||.:|
  Rat   210 SNT---DIDVILGGGRKFMFPKGTPDQEYPTDPQQAGTRLDGRNLVQEWLAKHQGAQYVWNRTEL 271

  Fly   309 LKLNVS-AVSSVIGLFQSKLMNFHLEADDTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDY 372
            ::.::: :|:.::|||:...|.::::.|.|..|:|:|:|||.:..||:|.: |::.|:|||.||:
  Rat   272 IQASLNRSVTHLMGLFEPNDMKYNIDRDPTQDPSLAEMTEVAVHMLSRNPK-GFYLFVEGGRIDH 335

  Fly   373 GNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDT 437
            |:|...|..||.||:.|:.|:..|..:|..:||:|:|||||.|..|..||..|...|.|:.....
  Rat   336 GHHEAIAYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGYTQREASIFGLAPFKA 400

  Fly   438 DINGVQYSVLNYAAGPNQYLDENGQRIPLDDILGSDDAITPSY-----IPKDQGVHSGEDVGIFA 497
            . :|..::.:.|..||...|: ||.|..:.:    :::..|:|     :|.....||||||.|||
  Rat   401 G-DGKSFTSILYGNGPGYKLN-NGIRADVTE----EESSNPTYQQQAAVPLSSETHSGEDVAIFA 459

  Fly   498 SGPQSHLFTGVMQQSTIPHLMAYAACI 524
            .|||:||..||.:|:.|.|:||:|.|:
  Rat   460 RGPQAHLVHGVQEQNYIAHVMAFAGCL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	183/448 (41%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	183/447 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129600
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9148
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860