DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp2 and Alpl

DIOPT Version :9

Sequence 1:	NP_611654.1	Gene:	Alp2 / 37539	FlyBaseID:	FBgn0283480	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_037191.2	Gene:	Alpl / 25586	RGDID:	2100	Length:	524	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	216/529 - (40%)
Similarity:	301/529 - (56%)	Gaps:	42/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IFLFLLAFVGTALGRVQEVHNVLELTGQKASKLRFSTDVATGKYTPPEEMDPQFWYKLADEEIAK 76
            |..||:..:||.|                           |..:.|.:|.||.:|.:.|.|.:..
  Rat     2 ILPFLVLAIGTCL---------------------------TNSFVPEKEKDPSYWRQQAQETLKN 39

  Fly    77 RLQLPQPNSDRAKNVIMFLGDGMPISTVTAARILKGQRQGNTGEESSLSFEKFPYSGLSRTYCAN 141
            .|:|.:.|::.|||:||||||||.:||||||||||||...|||||:.|..:|||:..||:||..|
  Rat    40 ALKLQKLNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTN 104

  Fly   142 AQVPDSACTATAYLCGVKTNIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTGFVTTT 206
            |||||||.||||||||||.|...:|||||.....|..:|  .|.:|||..||::||||.|.||||
  Rat   105 AQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQ--GNEVTSILRWAKDAGKSVGIVTTT 167

  Fly   207 TLTHASPSGAYAKTANRMWQSDTDVTSYGVDASTCVDMATQLVTQTPGKNFEVMFGGGMGKFLPK 271
            .:.||:||.|||.:|:|.|.||.::....: :..|.|:|.||:...  |:.:|:.|||.....||
  Rat   168 RVNHATPSAAYAHSADRDWYSDNEMPPEAL-SQGCKDIAYQLMHNI--KDIDVIMGGGRKYMYPK 229

  Fly   272 TTKD-----SHGKYGERSDGVNLLSRWQGL---HDKGVLVTNRKQLLNLDVSAASSIIGTFQSGL 328
            ...|     .....|.|.||::|:|.|:..   |.....|.||.:||.||.|....::|.|:.|.
  Rat   230 NRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGD 294

  Fly   329 MDFHMDADPTYQPTLSELTEVAIKKLSHNENGYFVFIEGGLIDYGNHYTQAGYALDEALEFEKAI 393
            |.:.::.:....|:|||:.|||::.|:.|..|:|:.:|||.||:|:|..:|..||.||:|.::||
  Rat   295 MQYELNRNNLTDPSLSEMVEVALRILTKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDEAI 359

  Fly   394 QLAREMTNISDTLIVVTADHGHAVSIAGYPGRGTPILGLNQHDTDINGVKYSVLNYAAGPN-QYL 457
            ..|..||:..|||.||||||.|..:..||..||..|.||....:|.:...::.:.|..||. :.:
  Rat   360 GKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVV 424

  Fly   458 DEHGQRIPLDDILGPDDAISPSYIDKEIGVHSGEDVGIWASGPQSHLFTGVMQQSTIPHLMAYAS 522
            |...:.:.:.| ...::..:.|.:......|.||||.::|.||.:||..||.:|:.|||:|||||
  Rat   425 DGERENVSMVD-YAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAS 488

  Fly   523 CVGSGKQVC 531
            |:|:....|
  Rat   489 CIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	196/444 (44%)
Alpl	NP_037191.2	Alk_phosphatase	51..490	CDD:395188	196/444 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9148
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760