Protein Alignment Alp2 and ALPG

DIOPT Version :9

• Sequence 1: NP_611654.1
• Gene: Alp2 / 37539
• FlyBaseID: FBgn0283480
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_112603.2
• Gene: ALPG / 251
• HGNCID: 441
• Length: 532
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 214/491 - (43%)
• Similarity: 289/491 - (58%)
• Gaps: 48/491 - (9%)

  Fly    57 PPEEMDPQFWYKLADEEI--AKRLQLPQPNSDRAKNVIMFLGDGMPISTVTAARILKGQRQGNTG 119
            |.||.:|.||.:.|.|.:  ||:|   ||....|||:|:||||||.:||||||||||||::...|
Human    22 PVEEENPDFWNRQAAEALGAAKKL---QPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLG 83

  Fly   120 EESSLSFEKFPYSGLSRTYCANAQVPDSACTATAYLCGVKTNIINIGVSAAVNFNNCTASQDPAN 184
            .|:.|:.::|||..||:||..:..||||..||||||||||.|...||:|||..||.|..::  .|
Human    84 PETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GN 146

  Fly   185 RLTSIAEWAQNAGKSTGFVTTTTLTHASPSGAYAKTANRMWQSDTDVTSYGVDASTCVDMATQLV 249
            .:.|:...|:.||||.|.||||.:.||||:||||.|.||.|.||.||.: ......|.|:||||:
Human   147 EVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPA-SARQEGCQDIATQLI 210

  Fly   250 TQTPGKNFEVMFGGGMGKFLPKTT-----KDSHGKYGERSDGVNLLSRWQGLHDKGVLVTNRKQL 309
            :   ..:.:|:.|||.....|..|     .|.:.:.|.|.||.||:..|...|.....|.||.:|
Human   211 S---NMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTEL 272

  Fly   310 L--NLDVSAASSIIGTFQSGLMDFHMDADPTYQPTLSELTEVAIKKLSHNENGYFVFIEGGLIDY 372
            |  :||.| .:.::|.|:.|.|.:.:..|.|..|:|.|:||.|:..||.|..|:|:|:|||.||:
Human   273 LQASLDPS-VTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDH 336

  Fly   373 GNHYTQAGYALDEALEFEKAIQLAREMTNISDTLIVVTADHGHAVSIAGYPGRGTPILGL---NQ 434
            |:|.::|..||.|.:.|:.||:.|.::|:..|||.:|||||.|..|..|||.||:.|.||   ..
Human   337 GHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKA 401

  Fly   435 HDTDINGVKYSVLNYAAGPNQYLDEHGQRIPLDDILGPD----DAISPSY-------IDKEIGVH 488
            .|..    .|:||.|..||. |:.:.|.|        ||    ::.||.|       :|.|  .|
Human   402 RDRK----AYTVLLYGNGPG-YVLKDGAR--------PDVTESESGSPEYRQQSAVPLDGE--TH 451

  Fly   489 SGEDVGIWASGPQSHLFTGVMQQSTIPHLMAYASCV 524
            :||||.::|.|||:||..||.:|:.|.|:||:|:|:
Human   452 AGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	200/457 (44%)
ALPG	NP_112603.2	PRK10518	25..475	CDD:236706	205/474 (43%)
		Alk_phosphatase	52..487	CDD:278666	200/456 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..443		7/28 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129600
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760