DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp2 and ALPP

DIOPT Version :9

Sequence 1:	NP_611654.1	Gene:	Alp2 / 37539	FlyBaseID:	FBgn0283480	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001623.3	Gene:	ALPP / 250	HGNCID:	439	Length:	535	Species:	Homo sapiens

Alignment Length:	540	Identity:	220/540 - (40%)
Similarity:	302/540 - (55%)	Gaps:	75/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LYPIFLFLLAFVGTALGRVQEVHNVLELTGQKASKLRFSTDVATGKYTPPEEMDPQFWYKLADEE 73
            |.|..|.||..:|.                    :|:.|..:     .|.||.:|.||.:.|.|.
Human     2 LGPCMLLLLLLLGL--------------------RLQLSLGI-----IPVEEENPDFWNREAAEA 41

  Fly    74 I--AKRLQLPQPNSDRAKNVIMFLGDGMPISTVTAARILKGQRQGNTGEESSLSFEKFPYSGLSR 136
            :  ||:|   ||....|||:|:||||||.:||||||||||||::...|.|..|:.::|||..||:
Human    42 LGAAKKL---QPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSK 103

  Fly   137 TYCANAQVPDSACTATAYLCGVKTNIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTG 201
            ||..:..||||..||||||||||.|...||:|||..||.|..::  .|.:.|:...|:.||||.|
Human   104 TYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVG 166

  Fly   202 FVTTTTLTHASPSGAYAKTANRMWQSDTDVTSYGVDASTCVDMATQLVTQTPGKNFEVMFGGG-- 264
            .||||.:.||||:|.||.|.||.|.||.||.: ......|.|:||||::   ..:.:|:.|||
Human   167 VVTTTRVQHASPAGTYAHTVNRNWYSDADVPA-SARQEGCQDIATQLIS---NMDIDVILGGGRK 227

  Fly   265 ----MGKFLPKTTKDSHGKYGERSDGVNLLSRWQGLHDKGVLVTNRKQLL--NLDVSAASSIIGT 323
                ||...|: ..|.:.:.|.|.||.||:..|.........|.||.:|:  :||.| .:.::|.
Human   228 YMFRMGTPDPE-YPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPS-VTHLMGL 290

  Fly   324 FQSGLMDFHMDADPTYQPTLSELTEVAIKKLSHNENGYFVFIEGGLIDYGNHYTQAGYALDEALE 388
            |:.|.|.:.:..|.|..|:|.|:||.|::.||.|..|:|:|:|||.||:|:|.::|..||.|.:.
Human   291 FEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIM 355

  Fly   389 FEKAIQLAREMTNISDTLIVVTADHGHAVSIAGYPGRGTPILGL---NQHDTDINGVKYSVLNYA 450
            |:.||:.|.::|:..|||.:|||||.|..|..|||.||:.|.||   ...|..    .|:||.|.
Human   356 FDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRK----AYTVLLYG 416

  Fly   451 AGPNQYLDEHGQRIPLDDILGPD----DAISPSY-------IDKEIGVHSGEDVGIWASGPQSHL 504
            .||. |:.:.|.|        ||    ::.||.|       :|:|  .|:||||.::|.|||:||
Human   417 NGPG-YVLKDGAR--------PDVTESESGSPEYRQQSAVPLDEE--THAGEDVAVFARGPQAHL 470

  Fly   505 FTGVMQQSTIPHLMAYASCV 524
            ..||.:|:.|.|:||:|:|:
Human   471 VHGVQEQTFIAHVMAFAACL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	198/458 (43%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	203/475 (43%)
		Alk_phosphatase	55..490	CDD:278666	198/457 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..449		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760