DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp2 and ALPL

DIOPT Version :9

Sequence 1:	NP_611654.1	Gene:	Alp2 / 37539	FlyBaseID:	FBgn0283480	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_000469.3	Gene:	ALPL / 249	HGNCID:	438	Length:	524	Species:	Homo sapiens

Alignment Length:	527	Identity:	208/527 - (39%)
Similarity:	295/527 - (55%)	Gaps:	44/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FLLAFVGTALGRVQEVHNVLELTGQKASKLRFSTDVATGKYTPPEEMDPQFWYKLADEEIAKRLQ 79
            ||:..:||.|                           |....|.:|.||::|...|.|.:...|:
Human     5 FLVLAIGTCL---------------------------TNSLVPEKEKDPKYWRDQAQETLKYALE 42

  Fly    80 LPQPNSDRAKNVIMFLGDGMPISTVTAARILKGQRQGNTGEESSLSFEKFPYSGLSRTYCANAQV 144
            |.:.|::.||||||||||||.:||||||||||||...|.|||:.|..:|||:..||:||..||||
Human    43 LQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQV 107

  Fly   145 PDSACTATAYLCGVKTNIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTGFVTTTTLT 209
            ||||.||||||||||.|...:|||||...:.|..:|  .|.:|||..||::||||.|.||||.:.
Human   108 PDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTSILRWAKDAGKSVGIVTTTRVN 170

  Fly   210 HASPSGAYAKTANRMWQSDTDVTSYGVDASTCVDMATQLVTQTPGKNFEVMFGGGMGKFLPKTTK 274
            ||:||.|||.:|:|.|.||.::....: :..|.|:|.||:...  ::.:|:.|||.....||...
Human   171 HATPSAAYAHSADRDWYSDNEMPPEAL-SQGCKDIAYQLMHNI--RDIDVIMGGGRKYMYPKNKT 232

  Fly   275 D-----SHGKYGERSDGVNLLSRWQGL---HDKGVLVTNRKQLLNLDVSAASSIIGTFQSGLMDF 331
            |     .....|.|.||::|:..|:..   :.....:.||.:||.||......::|.|:.|.|.:
Human   233 DVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQY 297

  Fly   332 HMDADPTYQPTLSELTEVAIKKLSHNENGYFVFIEGGLIDYGNHYTQAGYALDEALEFEKAIQLA 396
            .::.:....|:|||:..|||:.|..|..|:|:.:|||.||:|:|..:|..||.||:|.::||..|
Human   298 ELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQA 362

  Fly   397 REMTNISDTLIVVTADHGHAVSIAGYPGRGTPILGLNQHDTDINGVKYSVLNYAAGPNQYLDEHG 461
            ..:|:..|||.||||||.|..:..||..||..|.||....:|.:...::.:.|..||. |....|
Human   363 GSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG-YKVVGG 426

  Fly   462 QR--IPLDDILGPDDAISPSYIDKEIGVHSGEDVGIWASGPQSHLFTGVMQQSTIPHLMAYASCV 524
            :|  :.:.| ...::..:.|.:......|.||||.:::.||.:||..||.:|:.:||:||||:|:
Human   427 ERENVSMVD-YAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACI 490

  Fly   525 GSGKQVC 531
            |:....|
Human   491 GANLGHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	189/445 (42%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:333956	189/445 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760