Protein Alignment Alp2 and ALPI

DIOPT Version :9

• Sequence 1: NP_611654.1
• Gene: Alp2 / 37539
• FlyBaseID: FBgn0283480
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 210/506 - (41%)
• Similarity: 291/506 - (57%)
• Gaps: 38/506 - (7%)

  Fly    33 VLELTGQKASKLRFSTDVATGKYTPPEEMDPQFWYKLADE--EIAKRLQLPQPNSDRAKNVIMFL 95
            ||.|.|   .:|:.|..|     .|.||.:|.||.:.|.|  :.||:|   ||....|||:|:||
Human     6 VLLLLG---LRLQLSLGV-----IPAEEENPAFWNRQAAEALDAAKKL---QPIQKVAKNLILFL 59

  Fly    96 GDGMPISTVTAARILKGQRQGNTGEESSLSFEKFPYSGLSRTYCANAQVPDSACTATAYLCGVKT 160
            |||:.:.||||.||||||:.|..|.|:.|:.::|||..||:||..:.||||||.||||||||||.
Human    60 GDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKA 124

  Fly   161 NIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTGFVTTTTLTHASPSGAYAKTANRMW 225
            |...||:|||..||.|..::  .|.:.|:...|:.||||.|.||||.:.||||:|.||.|.||.|
Human   125 NFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNW 187

  Fly   226 QSDTDVTSYGVDASTCVDMATQLVTQTPGKNFEVMFGGGMGKFLPKTTKDSH-----GKYGERSD 285
            .||.|:.: ......|.|:||||::   ..:.:|:.|||.....|..|.|..     .:.|.|.|
Human   188 YSDADMPA-SARQEGCQDIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLD 248

  Fly   286 GVNLLSRWQGLHDKGVLVTNRKQLL--NLDVSAASSIIGTFQSGLMDFHMDADPTYQPTLSELTE 348
            |.||:..|...|.....|.||.:|:  :||.| .:.::|.|:.|...:.:..|||..|:|.|:||
Human   249 GKNLVQEWLAKHQGAWYVWNRTELMQASLDQS-VTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTE 312

  Fly   349 VAIKKLSHNENGYFVFIEGGLIDYGNHYTQAGYALDEALEFEKAIQLAREMTNISDTLIVVTADH 413
            .|::.||.|..|:::|:|||.||:|:|...|..||.||:.|:.||:.|.::|:..|||.:|||||
Human   313 AALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADH 377

  Fly   414 GHAVSIAGYPGRGTPILGLNQHDTDINGVKYSVLNYAAGPNQYLDEHGQRIPLDDILGPDDAISP 478
            .|..|..||..||:.|.||...... :...|:.:.|..||. |:...|.|..:::    .::.||
Human   378 SHVFSFGGYTLRGSSIFGLAPSKAQ-DSKAYTSILYGNGPG-YVFNSGVRPDVNE----SESGSP 436

  Fly   479 SY-----IDKEIGVHSGEDVGIWASGPQSHLFTGVMQQSTIPHLMAYASCV 524
            .|     :......|.||||.::|.|||:||..||.:||.:.|:||:|:|:
Human   437 DYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACL 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	189/448 (42%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	189/447 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760