DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp2 and Akp3

DIOPT Version :9

Sequence 1:	NP_611654.1	Gene:	Alp2 / 37539	FlyBaseID:	FBgn0283480	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	509	Identity:	212/509 - (41%)
Similarity:	287/509 - (56%)	Gaps:	45/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VLELTGQKASKLRFSTDVATGKYTPPEEMDPQFWYKLADE--EIAKRLQLPQPNSDRAKNVIMFL 95
            ||.|.|   .:|:.|..|     .|.||.:|.||.|.|.|  :.||:|   ||....|||:|:||
Mouse     6 VLLLLG---LRLQLSLSV-----IPVEEENPAFWNKKAAEALDAAKKL---QPIQTSAKNLIIFL 59

  Fly    96 GDGMPISTVTAARILKGQRQGNTGEESSLSFEKFPYSGLSRTYCANAQVPDSACTATAYLCGVKT 160
            ||||.:.||||.||||||.:|:.|.|:.|:.::|||..||:||..:.||||||.|||||||||||
Mouse    60 GDGMGVPTVTATRILKGQLEGHLGPETPLAMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKT 124

  Fly   161 NIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTGFVTTTTLTHASPSGAYAKTANRMW 225
            |...||||||..|:.|..:.  .|.:.|:...|:.||||.|.||||.:.||||||.|..|.||.|
Mouse   125 NYKTIGVSAAARFDQCNTTF--GNEVFSVMYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNW 187

  Fly   226 QSDTDVTSYGVDASTCVDMATQLVTQTPGKNFEVMFGGGMGKFLPKTTKDSH-----GKYGERSD 285
            ..|.|:.:..: ...|.|:||||::   ..:..|:.|||.....|..|.|..     .:.|.|.|
Mouse   188 YGDADMPASAL-REGCKDIATQLIS---NMDINVILGGGRKYMFPAGTPDPEYPNDANETGTRLD 248

  Fly   286 GVNLLSRWQGLHDKGVLVTNRKQLL-NLDVSAASSIIGTFQSGLMDFHMDADPTYQPTLSELTEV 349
            |.||:..|...|.....|.||:||: .....:.:.::|.|:.....|.:..||...|:|.::||.
Mouse   249 GRNLVQEWLSKHQGSQYVWNREQLIQKAQDPSVTYLMGLFEPVDTKFDIQRDPLMDPSLKDMTEA 313

  Fly   350 AIKKLSHNENGYFVFIEGGLIDYGNHYTQAGYALDEALEFEKAIQLAREMTNISDTLIVVTADHG 414
            |:|.||.|..|:::|:|||.||.|:|...|..||.||:.|:.||:.|.::|:..|||.:|||||.
Mouse   314 AVKVLSRNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHS 378

  Fly   415 HAVSIAGYPGRGTPILGLNQHDTDINGVKYSVLNYAAGPNQYLDEHGQRIPLDDILGPD----DA 475
            |..|..||..|||.|.||...:. ::|..|:.:.|..||. |:.. |:|        |:    ::
Mouse   379 HVFSFGGYTLRGTSIFGLAPLNA-LDGKPYTSILYGNGPG-YVGT-GER--------PNVTAAES 432

  Fly   476 ISPSY-----IDKEIGVHSGEDVGIWASGPQSHLFTGVMQQSTIPHLMAYASCV 524
            ...||     :..:...|.||||.|:|.|||:||..||.:|:.|.|:||:|.|:
Mouse   433 SGSSYRQQAAVPVKSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp2	NP_611654.1	ALP_like	89..525	CDD:304875	190/451 (42%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	190/450 (42%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760