DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and phu

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	219/530 - (41%)
Similarity:	314/530 - (59%)	Gaps:	48/530 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IHNQFQLVG-GSVSTAKTREGNLIDPNAMAKGKPG------PEEEKNAQFWYDLAYEEIAKRLEQ 85
            :|..|.|:| ||         |.|......:..|.      ..||:.|::|..||.:.:.::||.
  Fly    28 MHPVFSLMGTGS---------NPIGGGRYKRAMPQIVFDAVRSEERYAEYWQGLAAQTLDQQLES 83

  Fly    86 P-QLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTGEEDSLSFEKFPYTGLSRTYCSNAQV 149
            . :|:.:.|:||:||:|||||:.|:.|.|::.|      |||...:||:|||.|||:|||:|.||
  Fly    84 KLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG------GEEKQFAFEQFPYVGLSKTYCANMQV 142

  Fly   150 PDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPANQVDSIAAWAQAAGKATGIVTTTTLT 214
            .||||||||||.|||.|...:|::|||.|.:|......|:.|.|||||||..|.|||:||||::|
  Fly   143 ADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVT 207

  Fly   215 HASPSGAYAKTTNRFFESDTDILTYGEGQN-DPATCTDIATQLITQAPGKNFDVMLGGGIGKFLP 278
            ||||:|.||...||.:|:|.:::    |.| ||..|.|.|.|||....|:..:|::|||...|||
  Fly   208 HASPAGVYAHLANRNWENDAEVV----GDNGDPDLCPDAAAQLINSPVGQKLNVIMGGGRENFLP 268

  Fly   279 NTITDPFNKKGERSDGVNLLSRWQGLHPGGV-LAYNRNQLLSVNVSKITN-LIGTFRSGVMSFNK 341
            ..:||.....|.|.||.||:..|:..|.... ...||.:||  |:|..|: ::|.|....|:::.
  Fly   269 KGVTDSSGAPGRRLDGRNLIDEWKNQHTNSAQYVENRRELL--NLSNHTSRVLGLFAPYHMAYHL 331

  Fly   342 MADPKEEPTLAEMTRKAIEVVSKRDG--GYFLFVEGGLIDYGNHFNSPTYSLSETLQFEQAVQEA 404
            .|.|.|:|||.||.:.|:|::.::..  |||||||||.||:|:|......::.||.:|::||:.|
  Fly   332 DASPAEQPTLEEMVQSAMEILERQSAGRGYFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFA 396

  Fly   405 LDITDPEETLIVVTSDHAHPLTISGYPGRGTPILGLNQDDTDVNGVKYATLNYAVG---TNQYLD 466
            ...|..::|||||:|||:|.::::||..|...|.|:|......:.:.||||:||.|   .:.||.
  Fly   397 RSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGINDGQLAADDLPYATLSYANGPGYDSNYLR 461

  Fly   467 EHG-------QRIDLTDQIGAEDFIHPSYIHGTIGVHAGDDVGIFATGPQSHLFTGVMQQSTIPH 524
            |.|       :.|::.:    :||:.||.:......|.||||.:||:||.:.|||||.:|..|||
  Fly   462 EGGAVRRKNLRAINMKN----KDFMFPSTVPLESETHGGDDVAVFASGPYAQLFTGVFEQHFIPH 522

  Fly   525 LMAYASCIGN 534
            .:.||||:.:
  Fly   523 ALGYASCLSD 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	200/453 (44%)
phu	NP_649897.4	PhoA	71..524	CDD:224699	202/468 (43%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	199/452 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466639
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900