DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and alpl

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_957301.2	Gene:	alpl / 393982	ZFINID:	ZDB-GENE-040420-1	Length:	561	Species:	Danio rerio

Alignment Length:	526	Identity:	204/526 - (38%)
Similarity:	291/526 - (55%)	Gaps:	45/526 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KTREGNLIDPNAMA------------KGKPG---PEEEKNAQFWYDLAYEEIAKRLEQPQLDKRK 92
            |.|:..||| |.|.            :||..   ||:||...:|.|.|...:...|:..:|:|..
Zfish    24 KIRKRRLID-NKMKVVQLLILSCLVWEGKTKVQFPEQEKRPDYWRDFAQRSLKDALKLQELNKNI 87

  Fly    93 AKNVILFLGDGMSLSTVAAARIHKGQLKGNTGEEDSLSFEKFPYTGLSRTYCSNAQVPDSACTAT 157
            |||:||||||||.:.||.||||.||||.|..|||..|..:|||:..||:||.:||||||||.|||
Zfish    88 AKNIILFLGDGMGVPTVTAARILKGQLSGQNGEETQLEMDKFPHVALSKTYNTNAQVPDSAGTAT 152

  Fly   158 AYLCGVKTNIVALGITAAVSFNNCSGSEDPANQVDSIAAWAQAAGKATGIVTTTTLTHASPSGAY 222
            |:|||||.|...:|::||...:.|:.::  .|:|.||..||:.|||:.||||||.:.||:||.||
Zfish   153 AFLCGVKANEGTVGVSAAAVRSQCNTTQ--GNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAY 215

  Fly   223 AKTTNRFFESDTDILTYGEGQND--PATCTDIATQLITQAPGKNFDVMLGGGIGKFLPNTITD-- 283
            |...:|.:.||.|:      .|:  .:.|.|||.||....|  :.:|::|||.....|....|
Zfish   216 AHCVDRDWYSDADM------PNEALQSGCKDIARQLFENIP--DINVIMGGGRRSMYPKNTPDVE 272

  Fly   284 -PFNKK--GERSDGVNLLSRW--QGLHPGGVLAYNRNQLLSVNVSKITNLIGTFRSGVMSFNKMA 343
             |.:||  |.|.||.||:..|  :.....|...:|:..|||:|.:.:..|:|.|....:::....
Zfish   273 YPGDKKQNGTRKDGRNLVGEWIDRVKEKRGFYVWNKKDLLSLNPNNVDYLLGLFEPADLNYELER 337

  Fly   344 DPKEEPTLAEMTRKAIEVVSKRDGGYFLFVEGGLIDYGNHFNSPTYSLSETLQFEQAVQEALDIT 408
            :.:.:|:|.||...||:::.|.:.|:||.||||.||:|:|......:|.|.::.::|:..|..:|
Zfish   338 NTENDPSLTEMVDVAIKILKKNERGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLT 402

  Fly   409 DPEETLIVVTSDHAHPLTISGYPGRGTPILGLNQDDTDVNGVKYATLNYAVGTNQYLDEHGQRID 473
            ...:||.|||:||:|..:..||..||..|.||....:||:...:..:.|..|....| .:|.|
Zfish   403 SEYDTLTVVTADHSHVFSFGGYTPRGNSIFGLAPTLSDVDQKPFTAILYGNGPGFKL-VNGAR-- 464

  Fly   474 LTDQIGAEDFIHPSY-----IHGTIGVHAGDDVGIFATGPQSHLFTGVMQQSTIPHLMAYASCIG 533
              :.:...|:...:|     :...:..|.|:||.||:.||.:||..||.:|..|||:||||:|||
Zfish   465 --ENVSTVDYQQNNYQAQSAVPLRMETHGGEDVAIFSKGPMAHLLHGVQEQHYIPHVMAYAACIG 527

  Fly   534 NGPTLC 539
            .....|
Zfish   528 QNKDHC 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	181/452 (40%)
alpl	NP_957301.2	Alk_phosphatase	88..526	CDD:278666	181/452 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593255
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760