DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and ALPG

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_112603.2	Gene:	ALPG / 251	HGNCID:	441	Length:	532	Species:	Homo sapiens

Alignment Length:	493	Identity:	206/493 - (41%)
Similarity:	290/493 - (58%)	Gaps:	34/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PEEEKNAQFWYDLAYEEI--AKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTG 124
            |.||:|..||...|.|.:  ||:|:..|   ..|||:|:||||||.:|||.||||.|||.|...|
Human    22 PVEEENPDFWNRQAAEALGAAKKLQPAQ---TAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLG 83

  Fly   125 EEDSLSFEKFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPAN 189
            .|..|:.::|||..||:||..:..||||..||||||||||.|...:|::||..||.|:.:.  .|
Human    84 PETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTR--GN 146

  Fly   190 QVDSIAAWAQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYGEGQNDPAT-----C 249
            :|.|:...|:.|||:.|:||||.:.||||:||||.|.||.:.||.|:         ||:     |
Human   147 EVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADV---------PASARQEGC 202

  Fly   250 TDIATQLITQAPGKNFDVMLGGGIGKFLPNTITDP-----FNKKGERSDGVNLLSRWQGLHPGGV 309
            .|||||||:   ..:.||:||||.....|....||     :::.|.|.||.||:..|...|.|..
Human   203 QDIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGAR 264

  Fly   310 LAYNRNQLLSVNVS-KITNLIGTFRSGVMSFNKMADPKEEPTLAEMTRKAIEVVSKRDGGYFLFV 373
            ..:||.:||..::. .:|:|:|.|..|.|.:....|...:|:|.|||..|:.::|:...|:||||
Human   265 YVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFV 329

  Fly   374 EGGLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPIL 438
            |||.||:|:|.:....:|:||:.|:.|::.|..:|..|:||.:||:||:|..:..|||.||:.|.
Human   330 EGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIF 394

  Fly   439 GLNQDDTDVNGVKYATLNYAVGTNQYLDEHGQRIDLTD-QIGAEDFIHPSYIHGTIGVHAGDDVG 502
            ||...... :...|..|.|..|.. |:.:.|.|.|:|: :.|:.::...|.:......|||:||.
Human   395 GLAPGKAR-DRKAYTVLLYGNGPG-YVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVA 457

  Fly   503 IFATGPQSHLFTGVMQQSTIPHLMAYASCIGNGPTLCD 540
            :||.|||:||..||.:|:.|.|:||:|:|: ...|.||
Human   458 VFARGPQAHLVHGVQEQTFIAHVMAFAACL-EPYTACD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	190/450 (42%)
ALPG	NP_112603.2	PRK10518	25..475	CDD:236706	194/468 (41%)
		Alk_phosphatase	52..487	CDD:278666	190/450 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129600
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760