DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and ALPL

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_000469.3	Gene:	ALPL / 249	HGNCID:	438	Length:	524	Species:	Homo sapiens

Alignment Length:	492	Identity:	197/492 - (40%)
Similarity:	285/492 - (57%)	Gaps:	40/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PEEEKNAQFWYDLAYEEIAKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTGEE 126
            ||:||:.::|.|.|.|.:...||..:|:...|||||:||||||.:|||.||||.||||..|.|||
Human    20 PEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEE 84

  Fly   127 DSLSFEKFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPANQV 191
            ..|..:|||:..||:||.:||||||||.||||||||||.|...:|::||...:.|:.::  .|:|
Human    85 TRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEV 147

  Fly   192 DSIAAWAQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDI----LTYGEGQNDPATCTDI 252
            .||..||:.|||:.||||||.:.||:||.|||.:.:|.:.||.::    |:.|        |.||
Human   148 TSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQG--------CKDI 204

  Fly   253 ATQLITQAPGKNFDVMLGGGIGKFLPNTITD-----PFNKKGERSDGVNLLSRWQGLHP---GGV 309
            |.||:...  ::.||::|||.....|...||     ....:|.|.||::|:..|:...|   ...
Human   205 AYQLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSH 267

  Fly   310 LAYNRNQLLSVNVSKITNLIGTFRSGVMSFNKMADPKEEPTLAEMTRKAIEVVSKRDGGYFLFVE 374
            ..:||.:||:::...:..|:|.|..|.|.:....:...:|:|:||...||:::.|...|:||.||
Human   268 FIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVE 332

  Fly   375 GGLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPILG 439
            ||.||:|:|......:|.|.::.::|:.:|..:|..|:||.|||:||:|..|..||..||..|.|
Human   333 GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFG 397

  Fly   440 LNQDDTDVNGVKYATLNYAVGTNQYLDEHGQRIDLTDQIGAEDFIHPSY--------IHGTIGVH 496
            |....:|.:...:..:.|..|.. |....|:|    :.:...|:.|.:|        .|.|   |
Human   398 LAPMLSDTDKKPFTAILYGNGPG-YKVVGGER----ENVSMVDYAHNNYQAQSAVPLRHET---H 454

  Fly   497 AGDDVGIFATGPQSHLFTGVMQQSTIPHLMAYASCIG 533
            .|:||.:|:.||.:||..||.:|:.:||:||||:|||
Human   455 GGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	183/458 (40%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:333956	183/458 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3409
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.710