DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and ALPI

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001622.2	Gene:	ALPI / 248	HGNCID:	437	Length:	528	Species:	Homo sapiens

Alignment Length:	493	Identity:	198/493 - (40%)
Similarity:	286/493 - (58%)	Gaps:	34/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PEEEKNAQFWYDLAYE--EIAKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTG 124
            |.||:|..||...|.|  :.||:|:..|   :.|||:|||||||:.:.||.|.||.|||..|..|
Human    22 PAEEENPAFWNRQAAEALDAAKKLQPIQ---KVAKNLILFLGDGLGVPTVTATRILKGQKNGKLG 83

  Fly   125 EEDSLSFEKFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPAN 189
            .|..|:.::|||..||:||..:.||||||.||||||||||.|...:|::||..||.|:.:.  .|
Human    84 PETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTR--GN 146

  Fly   190 QVDSIAAWAQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYGEGQNDPAT-----C 249
            :|.|:...|:.|||:.|:||||.:.||||:|.||.|.||.:.||.|:         ||:     |
Human   147 EVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADM---------PASARQEGC 202

  Fly   250 TDIATQLITQAPGKNFDVMLGGGIGKFLPNTITDP-----FNKKGERSDGVNLLSRWQGLHPGGV 309
            .|||||||:   ..:.||:||||.....|....||     .::.|.|.||.||:..|...|.|..
Human   203 QDIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAW 264

  Fly   310 LAYNRNQLLSVNVSK-ITNLIGTFRSGVMSFNKMADPKEEPTLAEMTRKAIEVVSKRDGGYFLFV 373
            ..:||.:|:..::.: :|:|:|.|..|...:....||..:|:|.|||..|:.::|:...|::|||
Human   265 YVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFV 329

  Fly   374 EGGLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPIL 438
            |||.||:|:|......:|:|.:.|:.|::.|..:|..|:||.:||:||:|..:..||..||:.|.
Human   330 EGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIF 394

  Fly   439 GLNQDDTDVNGVKYATLNYAVGTNQYLDEHGQRIDLTD-QIGAEDFIHPSYIHGTIGVHAGDDVG 502
            ||...... :...|.::.|..|.. |:...|.|.|:.: :.|:.|:...:.:..:...|.|:||.
Human   395 GLAPSKAQ-DSKAYTSILYGNGPG-YVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVA 457

  Fly   503 IFATGPQSHLFTGVMQQSTIPHLMAYASCIGNGPTLCD 540
            :||.|||:||..||.:||.:.|:||:|:|: ...|.||
Human   458 VFARGPQAHLVHGVQEQSFVAHVMAFAACL-EPYTACD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	182/450 (40%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	182/450 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760