DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and Alpi

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_073156.3	Gene:	Alpi / 24197	RGDID:	2099	Length:	540	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	201/500 - (40%)
Similarity:	288/500 - (57%)	Gaps:	39/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PEEEKNAQFWYDLAYE--EIAKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTG 124
            |.||:|..||...|.|  ::||:|:..|   ..|||:||||||||.:.||.|.||.||||.|:.|
  Rat    23 PVEEENPVFWNQKAKEALDVAKKLQPIQ---TSAKNLILFLGDGMGVPTVTATRILKGQLGGHLG 84

  Fly   125 EEDSLSFEKFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPAN 189
            .|..|:.:.||:|.||:||..:.||||||.||||||||||.|...:|::||..||.|:.:.  .|
  Rat    85 PETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTF--GN 147

  Fly   190 QVDSIAAWAQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYG--EGQNDPATCTDI 252
            :|.|:...|:.|||:.|:||||.:.||||:|.||.|.||.:.||.|:.:..  ||      |.||
  Rat   148 EVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEG------CKDI 206

  Fly   253 ATQLITQAPGKNFDVMLGGGIGKFLPNTITDP-----FNKKGERSDGVNLLSRWQGLHPGGVLAY 312
            |||||:   ..:.||:||||.....|....||     .::.|.|.|..||:..|...:.|....:
  Rat   207 ATQLIS---NMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVW 268

  Fly   313 NRNQLLSVNVS-KITNLIGTFRSGVMSFNKMADPKEEPTLAEMTRKAIEVVSKRDGGYFLFVEGG 376
            ||.||:..:.. .:|.|:|.|....|.::...:...:|:|||||..|:.::|:...|::||||||
  Rat   269 NREQLMQASQDPAVTRLMGLFEPAEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGG 333

  Fly   377 LIDYGNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPILG-- 439
            .||.|:|..:...:|:|.:.|:.|:::|..:|:.::||.::|:||:|.....||..|||.|.|
  Rat   334 RIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLA 398

  Fly   440 -LNQDDTDVNGVKYATLNYAVGTNQYLDEHGQRIDLTD-QIGAEDFIHPSYIHGTIGVHAGDDVG 502
             ||..|    |..|.::.|..|.. |:...|.|.::|| :.|..::...:.:..:...|.|:||.
  Rat   399 PLNAQD----GKSYTSILYGNGPG-YVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVA 458

  Fly   503 IFATGPQSHLFTGVMQQSTIPHLMAYASCI------GNGPTLCDN 541
            |||.|||:||..||.:|:.|.|:||:|.|:      |..|...:|
  Rat   459 IFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADEN 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	185/456 (41%)
Alpi	NP_073156.3	Alk_phosphatase	53..488	CDD:278666	185/450 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760