DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and Alpp

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	196/487 - (40%)
Similarity:	290/487 - (59%)	Gaps:	37/487 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 PEEEKNAQFWYDLAYE--EIAKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTG 124
            |.||:|..||...|.|  |.||:|:..|   ..|.|:|:.:||||.:|||.|.||.|||.:|:.|
  Rat    21 PVEEENPAFWNRKAAEALEAAKKLQPIQ---TSANNLIILMGDGMGVSTVTATRILKGQQQGHLG 82

  Fly   125 EEDSLSFEKFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPAN 189
            .|..|:.::||:..||:||.::.||||||.|.||:|||||||:..:|::||..||.|:.:.  .|
  Rat    83 PETPLAMDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTW--GN 145

  Fly   190 QVDSIAAWAQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYG--EGQNDPATCTDI 252
            :|.|:...|:.|||:.|:||||::.||||:|.||.|.||.:.||..:.|..  ||      |.||
  Rat   146 EVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAHMSTAALQEG------CKDI 204

  Fly   253 ATQLITQAPGKNFDVMLGGGIGKFLPNTI------TDPFNKKGERSDGVNLLSRWQGLHPGGVLA 311
            |.|||:..   :.||:||||.....|...      ||| .:.|.|.||.||:..|...|.|....
  Rat   205 AMQLISNT---DIDVILGGGRKFMFPKGTPDQEYPTDP-QQAGTRLDGRNLVQEWLAKHQGAQYV 265

  Fly   312 YNRNQLLSVNVSK-ITNLIGTFRSGVMSFNKMADPKEEPTLAEMTRKAIEVVSKRDGGYFLFVEG 375
            :||.:|:..:::: :|:|:|.|....|.:|...||.::|:|||||..|:.::|:...|::|||||
  Rat   266 WNRTELIQASLNRSVTHLMGLFEPNDMKYNIDRDPTQDPSLAEMTEVAVHMLSRNPKGFYLFVEG 330

  Fly   376 GLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPILGL 440
            |.||:|:|......:|:|.:.|:.||.:|..:|..::|:|:||:||:|..:..||..|...|.||
  Rat   331 GRIDHGHHEAIAYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGYTQREASIFGL 395

  Fly   441 NQDDTDVNGVKYATLNYAVGTNQYLDEHGQRIDLTDQIGAEDFIHPSY-----IHGTIGVHAGDD 500
            ...... :|..:.::.|..|....|: :|.|.|:|:    |:..:|:|     :..:...|:|:|
  Rat   396 APFKAG-DGKSFTSILYGNGPGYKLN-NGIRADVTE----EESSNPTYQQQAAVPLSSETHSGED 454

  Fly   501 VGIFATGPQSHLFTGVMQQSTIPHLMAYASCI 532
            |.|||.|||:||..||.:|:.|.|:||:|.|:
  Rat   455 VAIFARGPQAHLVHGVQEQNYIAHVMAFAGCL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	182/453 (40%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	182/452 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129600
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860