DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp7 and alp3

DIOPT Version :9

Sequence 1:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	495	Identity:	191/495 - (38%)
Similarity:	284/495 - (57%)	Gaps:	36/495 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GPEEEKNAQFWYDLAYEEIAKRLEQPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTGE 125
            |..||:|.:||...|...:...|.: :::...|||::|||||||.::|:.||||.||||:.::||
Zfish    18 GSVEEENPEFWRKSAQNTLRSALSR-KINTNVAKNIVLFLGDGMGVTTITAARILKGQLQKHSGE 81

  Fly   126 EDSLSFEKFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPANQ 190
            |..::.:.||..||::.|..:.|:||||.||||||||||||:..:|::||.....|...:  .|:
Zfish    82 ETVMNMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSAAARNGVCRSQK--GNE 144

  Fly   191 VDSIAAWAQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYGEGQNDPAT-----CT 250
            |.||..||:.|||:.||||||.:.||:|:.::|.:.:|.:.||.|:         ||:     |.
Zfish   145 VTSILRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADL---------PASAATEGCV 200

  Fly   251 DIATQLITQAPGKNFDVMLGGGIGKFLPNTITDP-----FNKKGERSDGVNLLSRWQGLHPGGVL 310
            ||||||:...   :.||::|||.....|....||     .:.:|:|.||.||:..|..:..|.|.
Zfish   201 DIATQLLHNI---DIDVIIGGGRKYMTPKGFPDPEYPSDASAQGQRRDGRNLIQDWIQMKEGKVA 262

  Fly   311 AY--NRNQLLSVNVSKITNLIGTFRSGVMSFNKMADPKEEPTLAEMTRKAIEVVSKRDGGYFLFV 373
            .|  |:....:|:..|...|:..|....:.|:...|...:|:::|.|.|||:::.|...|:||.|
Zfish   263 RYVWNKTDFDAVDPEKTDYLMALFEPADLRFDVERDHSMDPSISETTDKAIQILKKNPKGFFLLV 327

  Fly   374 EGGLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPIL 438
            |||.||.|:|.:..:.:|.|.:..::||...|::||.||||.:||:||:|..|.:|||.||..||
Zfish   328 EGGRIDQGHHSSRASAALHEAVALDEAVSRGLELTDEEETLTIVTADHSHAFTFNGYPFRGNSIL 392

  Fly   439 GLNQDDTDVNGVKYATLNYAVGTNQYLDEHG----QRIDLTDQIGAEDFIHPSYIHGTIGVHAGD 499
            |.:..... :.:.|.||.|..|....:..:.    :::|..|    :|:|..|.:......|.|:
Zfish   393 GKSPIFAS-DFLPYTTLMYGNGPGHKITNNKRPDIRKVDTAD----KDYIQQSAVPLDSETHGGE 452

  Fly   500 DVGIFATGPQSHLFTGVMQQSTIPHLMAYASCIGNGPTLC 539
            ||.:||.||.:|||.||.:|:.|||.||||:|||.....|
Zfish   453 DVAVFARGPMAHLFQGVYEQNYIPHAMAYAACIGENQQHC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	179/454 (39%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	179/471 (38%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	179/454 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593216
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860