DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Swim and Tinagl1

DIOPT Version :9

Sequence 1:	NP_611652.2	Gene:	Swim / 37537	FlyBaseID:	FBgn0034709	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001161805.1	Gene:	Tinagl1 / 94242	MGIID:	2137617	Length:	466	Species:	Mus musculus

Alignment Length:	457	Identity:	190/457 - (41%)
Similarity:	253/457 - (55%)	Gaps:	53/457 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VGLLVLLMGGANALFDHTLK--------------RDFPGPYCARENTCCKDRHDGCSVPISNTLC 59
            :|||:||:.|..||.....:              ||..|.||..::.||:.|.|.|::|.....|
Mouse     6 LGLLLLLLAGQAALEARRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATC 70

  Fly    60 YCDEFCDRDDSSDCCPDYRSFCIG---EVDPIISCEHNGVYFSKYNTTWDNCNECRCLEGGSVQC 121
            |||.||:| ..||||||:..||:|   ...|:..|.|.|..:..:.|.|||||.|.|.|||..:|
Mouse    71 YCDLFCNR-TVSDCCPDFWDFCLGIPPPFPPVQGCMHGGRIYPVFGTYWDNCNRCTCHEGGHWEC 134

  Fly   122 DEDLCLTDDAIVHSVNSIHRLGWSARKYDQWWGRKYSEGLKLRLGTKEPTYRVKAMTRL---KNP 183
            |::.||.|..::.::|. ...||.|..:..:||....||::.||||..|:..|..|..:   ...
Mouse   135 DQEPCLVDPDMIKAINR-GNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSTVMNMNEIYTVLGQ 198

  Fly   184 TDGLPSSFNALDKWSSYISEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSAQNILSC-T 247
            .:.||::|.|.:||.:.|.|..|||.|..||..||.:|||||.:|.|.|.....||.||:||| |
Mouse   199 GEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDT 263

  Fly   248 RRQQGCEGGHLDAAWRYLHKKGVVDENCYPYT-----QHRDTCKIRHNSRSLR----------AN 297
            ..||||.||.||.||.:|.::|||.:||||::     :...|.:...:||::.          .|
Mouse   264 HHQQGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNEASPTPRCMMHSRAMGRGKRQATSRCPN 328

  Fly   298 GCQKPVNVDRDSLYTVGPAYSL-NREADIMAEIFHSGPVQATMRVNRDFFAYSGGVYRETAANRK 361
            |     .||.:.:|.|.|||.| :.|.:||.|:..:|||||.|.|:.|||.|..|:|..|..::.
Mouse   329 G-----QVDSNDIYQVTPAYRLGSDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQG 388

  Fly   362 APT-----GFHSVKLVGWGEE--HNGE--KYWIAANSWGSWWGEHGYFRILRGSNECGIEEYVLA 417
            .|.     |.||||:.|||||  .:|.  |||.||||||.||||.|:|||:||:|||.||.:||.
Mouse   389 RPEQYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGTNECDIETFVLG 453

  Fly   418 SW 419
            .|
Mouse   454 VW 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385	21/41 (51%)
		VWC	91..>126	CDD:302663	16/34 (47%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	117/254 (46%)
Tinagl1	NP_001161805.1	Somatomedin_B	53..93	CDD:279385	21/40 (53%)
		VWC	104..>152	CDD:302663	20/48 (42%)
		Peptidase_C1A_CathepsinB	203..454	CDD:239111	118/255 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2647
eggNOG	1	0.900	-	-		E1_KOG1544
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41472
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2248
Isobase	1	0.950	-	0	Normalized mean entropy	S3776
OMA	1	1.010	-	-		QHG46598
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007265
OrthoInspector	1	1.000	-	-		otm43599
orthoMCL	1	0.900	-	-		OOG6_106867
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5102
SonicParanoid	1	1.000	-	-		X3555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810