DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Swim and Tinagl1

DIOPT Version :9

Sequence 1:	NP_611652.2	Gene:	Swim / 37537	FlyBaseID:	FBgn0034709	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_446034.1	Gene:	Tinagl1 / 94174	RGDID:	70956	Length:	467	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	187/454 - (41%)
Similarity:	248/454 - (54%)	Gaps:	46/454 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VGLLVLLMGGANALFDHTLK--------------RDFPGPYCARENTCCKDRHDGCSVPISNTLC 59
            :|||:||:.|..||.....:              ||..|.||..::.||:.|.|.|::|.....|
  Rat     6 LGLLLLLLAGQAALEARRSRWRRELAPGLHLRGIRDAGGRYCQEQDMCCRGRADECALPYLGATC 70

  Fly    60 YCDEFCDRDDSSDCCPDYRSFCIG---EVDPIISCEHNGVYFSKYNTTWDNCNECRCLEGGSVQC 121
            |||.||:| ..||||||:..||:|   ...|:..|.|.|..:..:.|.|:|||.|.|.|.|..:|
  Rat    71 YCDLFCNR-TVSDCCPDFWDFCLGIPPPFPPVQGCMHAGRIYPIFGTYWENCNRCTCHEKGQWEC 134

  Fly   122 DEDLCLTDDAIVHSVNSIHRLGWSARKYDQWWGRKYSEGLKLRLGTKEPTYRVKAMTRL---KNP 183
            |::.||.|.|::.::|. ...||.|..:..:||....||::.||||..|:..|..|..:   ...
  Rat   135 DQEPCLVDPAMIKAINR-GNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMNEIYTVLGQ 198

  Fly   184 TDGLPSSFNALDKWSSYISEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSAQNILSC-T 247
            .:.||::|.|.:||.:.|.|..|||.|..||..||.:|||||.:|.|.|.....||.||:||| |
  Rat   199 GEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPILSPQNLLSCDT 263

  Fly   248 RRQQGCEGGHLDAAWRYLHKKGVVDENCYPYTQHRDTCKIRHNSRSL---RANG---------CQ 300
            ..|:||.||.||.||.:|.::|||.:||||::......:.....|.:   ||.|         |.
  Rat   264 HHQKGCRGGRLDGAWWFLRRRGVVSDNCYPFSGREQNDEASPTPRCMMHSRAMGRGKRQATSRCP 328

  Fly   301 KPVNVDRDSLYTVGPAYSL-NREADIMAEIFHSGPVQATMRVNRDFFAYSGGVYRETAANRKAPT 364
            .. .||.:.:|.|.|.|.| :.|.:||.|:..:|||||.|.|:.|||.|..|:|..|..::..|.
  Rat   329 NS-QVDSNDIYQVTPVYRLASDEKEIMKELMENGPVQALMEVHEDFFLYQRGIYSHTPVSQGRPE 392

  Fly   365 -----GFHSVKLVGWGEE--HNGE--KYWIAANSWGSWWGEHGYFRILRGSNECGIEEYVLASW 419
                 |.||||:.|||||  .:|.  |||.||||||.||||.|:|||:||.|||.||.:||..|
  Rat   393 QYRRHGTHSVKITGWGEETLPDGRTIKYWTAANSWGPWWGERGHFRIVRGINECDIETFVLGVW 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385	21/41 (51%)
		VWC	91..>126	CDD:302663	14/34 (41%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	115/251 (46%)
Tinagl1	NP_446034.1	Somatomedin_B	53..93	CDD:279385	21/40 (53%)
		VWC	104..>152	CDD:302663	19/48 (40%)
		Peptidase_C1A_CathepsinB	203..455	CDD:239111	116/252 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	214	1.000	Domainoid score	I2657
eggNOG	1	0.900	-	-		E1_KOG1544
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41472
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2245
OMA	1	1.010	-	-		QHG46598
OrthoDB	1	1.010	-	-		D1436535at2759
OrthoFinder	1	1.000	-	-		FOG0007265
OrthoInspector	1	1.000	-	-		otm45671
orthoMCL	1	0.900	-	-		OOG6_106867
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3555
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840