Protein Alignment Swim and TINAGL1

DIOPT Version :10

• Sequence 1: NP_611652.2
• Gene: Swim / 37537
• FlyBaseID: FBgn0034709
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_071447.1
• Gene: TINAGL1 / 64129
• HGNCID: 19168
• Length: 467
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 189/455 - (41%)
• Similarity: 253/455 - (55%)
• Gaps: 48/455 - (10%)

  Fly     9 VGLLVLL-MGGANALFDHTLK--------------RDFPGPYCARENTCCKDRHDGCSVPISNTL 58
            :|||:|| :.|..||.....:              ||..|.||..::.||:.|.|.|::|....:
Human     6 LGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGAI 70

  Fly    59 CYCDEFCDRDDSSDCCPDYRSFCIG---EVDPIISCEHNGVYFSKYNTTWDNCNECRCLEGGSVQ 120
            ||||.||:| ..||||||:..||:|   ...||..|.|.|..:....|.|||||.|.|.|....|
Human    71 CYCDLFCNR-TVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQ 134

  Fly   121 CDEDLCLTDDAIVHSVNSIHRLGWSARKYDQWWGRKYSEGLKLRLGTKEPTYRVKAMTRL---KN 182
            ||::.||.|..::.::|. ...||.|..:..:||....||::.||||..|:..|..|..:   .|
Human   135 CDQEPCLVDPDMIKAINQ-GNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLN 198

  Fly   183 PTDGLPSSFNALDKWSSYISEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSAQNILSC- 246
            |.:.||::|.|.:||.:.|.|..|||.|..||..||.:|||||.:|.|.|.....||.||:|||
Human   199 PGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCD 263

  Fly   247 TRRQQGCEGGHLDAAWRYLHKKGVVDENCYPYT-QHRD------TCKIRHNSRSLRANGCQKPVN 304
            |.:||||.||.||.||.:|.::|||.::|||:: :.||      .|.:  :||::.....|...:
Human   264 THQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMM--HSRAMGRGKRQATAH 326

  Fly   305 -----VDRDSLYTVGPAYSL-NREADIMAEIFHSGPVQATMRVNRDFFAYSGGVYRETAANRKAP 363
                 |:.:.:|.|.|.|.| :.:.:||.|:..:|||||.|.|:.|||.|.||:|..|..:...|
Human   327 CPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRP 391

  Fly   364 T-----GFHSVKLVGWGEE--HNGE--KYWIAANSWGSWWGEHGYFRILRGSNECGIEEYVLASW 419
            .     |.||||:.|||||  .:|.  |||.||||||..|||.|:|||:||.|||.||.:||..|
Human   392 ERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVW 456

  Fly   420  419
            Human   457  456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..84	CDD:460034	22/45 (49%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	114/251 (45%)
TINAGL1	NP_071447.1	Somatomedin_B	54..94	CDD:470596	21/40 (53%)
		VWC	105..>140	CDD:450195	15/34 (44%)
		Peptidase_C1A_CathepsinB	204..455	CDD:239111	115/252 (46%)