DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Swim and CG4847

DIOPT Version :9

Sequence 1:	NP_611652.2	Gene:	Swim / 37537	FlyBaseID:	FBgn0034709	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_725686.1	Gene:	CG4847 / 36973	FlyBaseID:	FBgn0034229	Length:	420	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	101/357 - (28%)
Similarity:	153/357 - (42%)	Gaps:	61/357 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PIIS-CEHNGVYFSKYNTTWDNCNECRCLEGGSVQCDEDLCLTDDAI----VH----SVNSIHRL 142
            |::| .:..|.:.|:...|:.:..: |.|..|:....::|....:|.    ||    :||:...|
  Fly   104 PLLSNVQDFGDFLSQSGKTYLSAAD-RALHEGAFASTKNLVEAGNAAFAQGVHTFKQAVNAFADL 167

  Fly   143 GWSARKYDQWWGRKYSEGLKLRLGTK---EPTYRVKAMTRLKN-PTDGLPSSFNALDKWSSY--I 201
                         .:||.|....|.|   |...|..|..:|.| |...:|.:|:    |..:  :
  Fly   168 -------------THSEFLSQLTGLKRSPEAKARAAASLKLVNLPAKPIPDAFD----WREHGGV 215

  Fly   202 SEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSAQNILSCTRRQ----QGCEGGHLDAAW 262
            :.|..||.||:.|..:||.........::....|  ||.||::.|...:    .||:||..:||:
  Fly   216 TPVKFQGTCGSCWAFATTGAIEGHTFRKTGSLPN--LSEQNLVDCGPVEDFGLNGCDGGFQEAAF 278

  Fly   263 RYLH--KKGVVDENCYPYTQHRDTCKIRHNSRSLRANGCQKPVNVDRDSLYTVGPAYSLNREADI 325
            .::.  :|||..|..|||..::.|||...:.......|.......|.:.|..|
  Fly   279 CFIDEVQKGVSQEGAYPYIDNKGTCKYDGSKSGATLQGFAAIPPKDEEQLKKV------------ 331

  Fly   326 MAEIFHSGPVQATMRVNRDFFAYSGGVYRETAANRKAPTGFHSVKLVGWGEEHNGEKYWIAANSW 390
               :...|||..::........|:||:|.:...|:..|.  ||:.:||:|.| .|:.|||..|||
  Fly   332 ---VATLGPVACSVNGLETLKNYAGGIYNDDECNKGEPN--HSILVVGYGSE-KGQDYWIVKNSW 390

  Fly   391 GSWWGEHGYFRILRGSNECGIEEYVLASWPYV 422
            ...|||.||||:.||.|.|.|.|.  .|:|.|
  Fly   391 DDTWGEKGYFRLPRGKNYCFIAEE--CSYPVV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385
		VWC	91..>126	CDD:302663	6/34 (18%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	72/236 (31%)
CG4847	NP_725686.1	Inhibitor_I29	112..172	CDD:285458	14/73 (19%)
CG4847	NP_725686.1	Peptidase_C1A	204..418	CDD:239068	73/239 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840