DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Swim and Ctsf

DIOPT Version :9

Sequence 1:	NP_611652.2	Gene:	Swim / 37537	FlyBaseID:	FBgn0034709	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001029282.1	Gene:	Ctsf / 361704	RGDID:	1308181	Length:	462	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	72/260 - (27%)
Similarity:	107/260 - (41%)	Gaps:	40/260 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 TKEPTYRVKAMTRLKNPTDG---LPSSFNAL--DKW----SSYISEVPDQGWCGASWVLSTTSVA 222
            |:|..:.:.....|:..:.|   |..|.|.|  .:|    ...::||.|||.||:.|..|.|...
  Rat   218 TEEEFHTIYLNPLLQKESGGKMSLAKSINDLAPPEWDWRKKGAVTEVKDQGMCGSCWAFSVTGNV 282

  Fly   223 SDRFAIQSKGKENVQLSAQNILSCTRRQQGCEGGHLDAAWRYLHKKGVVD-ENCYPYTQHRDTCK 286
            ..::.: ::| ..:.||.|.:|.|.:..:.|.||....|:..:...|.:: |:.|.|..|...|.
  Rat   283 EGQWFL-NRG-TLLSLSEQELLDCDKMDKACMGGLPSNAYTAIKNLGGLETEDDYGYQGHVQACN 345

  Fly   287 IRHNSRSLRANGCQKPVNVDRDSLYTVGPAYSLNREADIMAEIFHSGPVQATMRVNRDFFAYSGG 351
            .......:..|   ..|.:.||             |..|.|.:...||:...:.      |:...
  Rat   346 FSTQMAKVYIN---DSVELSRD-------------ENKIAAWLAQKGPISVAIN------AFGMQ 388

  Fly   352 VYRETAANRKAPTGF-----HSVKLVGWGEEHNGEKYWIAANSWGSWWGEHGYFRILRGSNECGI 411
            .||...|:...|...     |:|.|||:|...| ..||...||||..|||.||:.:.|||..||:
  Rat   389 FYRHGIAHPFRPLCSPWFIDHAVLLVGYGNRSN-IPYWAIKNSWGRDWGEEGYYYLYRGSGACGV 452

Fly 412 411
Rat 453 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385
		VWC	91..>126	CDD:302663
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	67/236 (28%)
Ctsf	NP_001029282.1	Inhibitor_I29	165..221	CDD:214853	1/2 (50%)
Ctsf	NP_001029282.1	Peptidase_C1	249..460	CDD:395062	64/229 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930