DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Swim and Tinag

DIOPT Version :9

Sequence 1:	NP_611652.2	Gene:	Swim / 37537	FlyBaseID:	FBgn0034709	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001005549.1	Gene:	Tinag / 300846	RGDID:	1359482	Length:	475	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	168/422 - (39%)
Similarity:	235/422 - (55%)	Gaps:	40/422 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FPGPYCARENTCCKDRHDGCSVPI--SNTLCYCDEFCDRDDSSDCCPDYRSFC-IGEVDPII--- 89
            |.|.||.|.. ||:.|.|.|....  :|.|||||.||:| |:|||||||:||| .|:..|.:
  Rat    52 FQGEYCRRFG-CCEARDDTCVTQFYEANALCYCDSFCER-DTSDCCPDYKSFCREGKDGPPLQQP 114

  Fly    90 ----SCEHNGVYFSKYNTTWDNCNECRCLEGGSVQCDEDLCLTDDAIVHSVNSIHRLGWSARKYD 150
                .|..:..::.:.:...:|||.|.| .|...:|.:.:||....::..:|. ...||:|:.|.
  Rat   115 LDPEGCSRDSQHYEEGSVIKENCNFCTC-SGQQWKCSQHVCLVLPELIDHINK-GDYGWTAQNYS 177

  Fly   151 QWWGRKYSEGLKLRLGTKEPTYRVKAMTRL--KNPTDGLPSSFNALDKWSSYISEVPDQGWCGAS 213
            |:||....||.|.||||..|:..:.:|..:  ..|...||..|.|..||..:.....||..|.||
  Rat   178 QFWGMTLEEGFKFRLGTLPPSPMLLSMNEMTASYPRADLPEVFIASYKWPGWTHGPLDQKNCAAS 242

  Fly   214 WVLSTTSVASDRFAIQSKGKENVQLSAQNILS-CTRRQQGCEGGHLDAAWRYLHKKGVVDENCYP 277
            |..||.|||:||.||||||:....||.||::| |.:.:.||..|.:|.||.:|.|:|:|...|||
  Rat   243 WAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWFLRKRGLVSHACYP 307

  Fly   278 YTQHRDTCKIRHNSRSL--RANGCQK-------PVNVDRDS-LYTVGPAYSL-NREADIMAEIFH 331
            ..:.:.|   .:||.::  |::|..|       |.:.::.: :|...|.|.: :.|.:||.||..
  Rat   308 LFKEQST---NNNSCAMASRSDGRGKRHATRPCPNSFEKSNRIYQCSPPYRISSNETEIMREIIQ 369

  Fly   332 SGPVQATMRVNRDFFAYSGGVYRETAANRKAPTGF-----HSVKLVGW----GEEHNGEKYWIAA 387
            :|||||.|:|:.|||.|..|:||...:..:.|..:     |:|||.||    |.:...||:||||
  Rat   370 NGPVQAIMQVHEDFFYYKTGIYRHVVSTNEEPEKYRKLRTHAVKLTGWGTLRGAQGKKEKFWIAA 434

  Fly   388 NSWGSWWGEHGYFRILRGSNECGIEEYVLASW 419
            ||||..|||:||||||||.||..||:.::|:|
  Rat   435 NSWGKSWGENGYFRILRGVNESDIEKLIIAAW 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385	25/44 (57%)
		VWC	91..>126	CDD:302663	8/34 (24%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	105/249 (42%)
Tinag	NP_001005549.1	Somatomedin_B	61..104	CDD:366428	25/44 (57%)
Tinag	NP_001005549.1	Peptidase_C1A_CathepsinB	217..465	CDD:239111	105/250 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343576
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46598
OrthoDB	1	1.010	-	-		D1436535at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45671
orthoMCL	1	0.900	-	-		OOG6_106867
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3555
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860