DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Swim and cpr-8

DIOPT Version :9

Sequence 1:	NP_611652.2	Gene:	Swim / 37537	FlyBaseID:	FBgn0034709	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_503384.1	Gene:	cpr-8 / 178613	WormBaseID:	WBGene00021070	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	350	Identity:	107/350 - (30%)
Similarity:	158/350 - (45%)	Gaps:	66/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 CLEGGSVQCDEDLCLTDDAIVHSVNSIHRLGWSARKYDQWWGRKYSEGL-KLRLGTKEPTYRVKA 176
            ||.|...|.|.......|.|:|.||| .:..|:|             |: .|...:...|....|
Worm     7 CLIGVLFQADGVPPSEIDRIIHYVNS-QKTTWTA-------------GIPALSRNSMLKTLVTDA 57

  Fly   177 MT---RLKN-----PTDGLPSSFNALDKWSSYIS--EVPDQGWCGASWVLSTTSVASDRFAIQSK 231
            .|   :::|     ....|..||:|.::|...:|  ::.|...|..||..:.....|||..|.|.
Worm    58 ATIGFKIQNFGVSQANSDLSPSFDARERWPECMSIPQINDISECKTSWAFAAAESMSDRLCINSG 122

  Fly   232 GKENVQLSAQNILSCTRRQ----QGCEGGHLDAAWRYLHKKGV-------VDENCYPY------- 278
            |.:|..|||:.:|||....    :|||||:...||:|:.|.|:       ....|.||
Worm   123 GFKNTILSAEELLSCCTGMFSCGEGCEGGNPFKAWQYIQKHGIPTGGSYESQFGCKPYSIPPCGK 187

  Fly   279 -------------TQHRDTCKIRHNSRSLRANGCQKPVNVDRDSLYTVGPAYSLNREADIMAEIF 330
                         |....:|:.:..||      ...|:::|:|..|.|......|.:.:|.:::.
Worm   188 TVGNVTYPACTNTTSPTPSCEKKCTSR------IGYPIDIDKDRHYGVSVDQLPNSQIEIQSDVM 246

  Fly   331 HSGPVQATMRVNRDFFAYSGGVYRETAANRKAPTGFHSVKLVGWGEEHNGEKYWIAANSWGSWWG 395
            .:||:|||..|..||..|:.|:|.....|::   |..||:::||| ...|..||:.|||||..||
Worm   247 LNGPIQATFEVYDDFLQYTTGIYVHLTGNKQ---GHLSVRIIGWG-VWQGVPYWLCANSWGRQWG 307

  Fly   396 EHGYFRILRGSNECGIEEYVLASWP 420
            |:|.||:|||:||||:|...::..|
Worm   308 ENGTFRVLRGTNECGLESNCVSGMP 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385
		VWC	91..>126	CDD:302663	5/12 (42%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	86/261 (33%)
cpr-8	NP_503384.1	Propeptide_C1	24..>40	CDD:369701	8/29 (28%)
cpr-8	NP_503384.1	Peptidase_C1A_CathepsinB	79..330	CDD:239111	86/260 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3776
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860