Protein Alignment Swim and F26E4.3

DIOPT Version :9

• Sequence 1: NP_611652.2
• Gene: Swim / 37537
• FlyBaseID: FBgn0034709
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_492593.2
• Gene: F26E4.3 / 172827
• WormBaseID: WBGene00009158
• Length: 452
• Species: Caenorhabditis elegans
• Alignment Length: 412
• Identity: 183/412 - (44%)
• Similarity: 252/412 - (61%)
• Gaps: 33/412 - (8%)

  Fly    32 PGPYCA-RENTCCKDRHDGCSVPI-SNTLCYCDEFCDR--DDSSDCCPDYRSFCIG---EVDPII 89
            ||.||: |.:|||::|.|.|:||| .:.|||||.||||  |..:|||||:.:.|.|   :.|..|
 Worm    27 PGDYCSVRTHTCCENRDDDCTVPILGDHLCYCDMFCDRGPDGGNDCCPDFEATCRGKDIQNDQRI 91

  Fly    90 ---SCEHNGVYFSKYNTTWDNCNECRCLEGGSVQCDEDLCLTDDAIVHSVNSIHRLGWSARKYDQ 151
               ||..:|      :|...||.:|.| ..|..:||...||....|:..::: .|..||||.|..
 Worm    92 DGESCSMDG------DTKEKNCEKCTC-HNGFWKCDGTACLIQPDILEKIHT-GRYSWSARNYSA 148

  Fly   152 WWGRKYSEGLKLRLGTKEPTYRVKAMTRLKNPTDGLPSSFNALDKWSSYISEVPDQGWCGASWVL 216
            :|||..|:|:|.||||..|...|:.|..:......||..|:|.|||...|..|.|||.||:||.:
 Worm   149 FWGRSLSDGIKYRLGTLFPERSVQNMNEILIKPRELPEHFDARDKWGPLIHPVADQGDCGSSWSV 213

  Fly   217 STTSVASDRFAIQSKGKENVQLSAQNILSCTR-RQQGCEGGHLDAAWRYLHKKGVVDENCYPYT- 279
            |||:::|||.||.|:|:.|..||:|.:|||.: ||:|||||:||.||.|:.|.|||.::||||.
 Worm   214 STTAISSDRLAIISEGRINSTLSSQQLLSCNQHRQKGCEGGYLDRAWWYIRKLGVVGDHCYPYVS 278

  Fly   280 -QHRDT--CKIRHNSRSLRANGCQKPVNVDRDSLYTVGPAYSL-NREADIMAEIFHSGPVQATMR 340
             |.|:.  |.|.....:.| .|.:.|......:.:.:.|.|.: :||.||..|:..:||||||..
 Worm   279 GQSREPGHCLIPKRDYTNR-QGLRCPSGSQDSTAFKMTPPYKVSSREEDIQTELMTNGPVQATFV 342

  Fly   341 VNRDFFAYSGGVYR--ETAANRKAPT---GFHSVKLVGWGEEHN-GE--KYWIAANSWGSWWGEH 397
            |:.|||.|:||||:  :.||.:.|.:   |:|||:::|||.:|: |:  |||:.|||||:.|||.
 Worm   343 VHEDFFMYAGGVYQHSDLAAQKGASSVAEGYHSVRVLGWGVDHSTGKPIKYWLCANSWGTQWGED 407

  Fly   398 GYFRILRGSNECGIEEYVLASW 419
            |||::|||.|.|.||.:|:.:|
 Worm   408 GYFKVLRGENHCEIESFVIGAW 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385	25/44 (57%)
		VWC	91..>126	CDD:302663	10/34 (29%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	115/242 (48%)
F26E4.3	NP_492593.2	Somatomedin_B	37..82	CDD:279385	25/44 (57%)
		Peptidase_C1A_CathepsinB	185..428	CDD:239111	115/243 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166367
Domainoid	1	1.000	219	1.000	Domainoid score	I1518
eggNOG	1	0.900	-	-		E1_KOG1544
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41472
Inparanoid	1	1.050	331	1.000	Inparanoid score	I1436
Isobase	1	0.950	-	0	Normalized mean entropy	S3776
OMA	1	1.010	-	-		QHG46598
OrthoDB	1	1.010	-	-		D1436535at2759
OrthoFinder	1	1.000	-	-		FOG0007265
OrthoInspector	1	1.000	-	-		oto17635
orthoMCL	1	0.900	-	-		OOG6_106867
Panther	1	1.100	-	-	LDO	PTHR12411
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5102
SonicParanoid	1	1.000	-	-		X3555
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790