Protein Alignment Swim and CTSW

DIOPT Version :9

• Sequence 1: NP_611652.2
• Gene: Swim / 37537
• FlyBaseID: FBgn0034709
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_001326.3
• Gene: CTSW / 1521
• HGNCID: 2546
• Length: 376
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 84/333 - (25%)
• Similarity: 128/333 - (38%)
• Gaps: 79/333 - (23%)

  Fly   130 DAIVHSVNSIHRL----------------GWSARKYDQWWGRKYSEGLKLRLGTKEPTYRVKAMT 178
            |...|::....||                ..:..::.|.:|.:.:.|....:|.:         .
Human    64 DIFAHNLAQAQRLQEEDLGTAEFGVTPFSDLTEEEFGQLYGYRRAAGGVPSMGRE---------I 119

  Fly   179 RLKNPTDGLPSSFNALDKW---SSYISEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSA 240
            |.:.|.:.:|.|.:    |   :|.||.:.||..|...|.::........:.|..  .:.|.:|.
Human   120 RSEEPEESVPFSCD----WRKVASAISPIKDQKNCNCCWAMAAAGNIETLWRISF--WDFVDVSV 178

  Fly   241 QNILSCTRRQQGCEGGHL-DAAWRYLHKKGVVDENCYPYTQHRDTCKIRHNSRSLRANGC----- 299
            |.:|.|.|...||.||.: ||....|:..|:..|..||:            ...:||:.|
Human   179 QELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPF------------QGKVRAHRCHPKKY 231

  Fly   300 QKPVNVDRDSLYTVGPAYSLNREADIMAEIFHSGPVQATMRVNRDFFAYSGGVYRETAANRKAPT 364
            ||...: :|.:..      .|.|..|...:...||:..|:.: :....|..||.:.|........
Human   232 QKVAWI-QDFIML------QNNEHRIAQYLATYGPITVTINM-KPLQLYRKGVIKATPTTCDPQL 288

  Fly   365 GFHSVKLVGWGEEHNGE-------------------KYWIAANSWGSWWGEHGYFRILRGSNECG 410
            ..|||.|||:|...:.|                   .|||..||||:.|||.||||:.||||.||
Human   289 VDHSVLLVGFGSVKSEEGIWAETVSSQSQPQPPHPTPYWILKNSWGAQWGEKGYFRLHRGSNTCG 353

  Fly   411 IEEYVLAS 418
            |.::.|.:
Human   354 ITKFPLTA 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385
		VWC	91..>126	CDD:302663
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	73/256 (29%)
CTSW	NP_001326.3	Inhibitor_I29	42..98	CDD:214853	4/33 (12%)
		Peptidase_C1A	129..358	CDD:239068	73/254 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840