Protein Alignment Swim and CTSS

DIOPT Version :10

• Sequence 1: NP_611652.2
• Gene: Swim / 37537
• FlyBaseID: FBgn0034709
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_004070.3
• Gene: CTSS / 1520
• HGNCID: 2545
• Length: 331
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 87/271 - (32%)
• Similarity: 133/271 - (49%)
• Gaps: 33/271 - (12%)

  Fly   159 EGLKLRLGTKEPTYRVKAMTRLKNPTDGLPSSFNALDKWSSYISEVPDQGWCGASWVLSTTSVAS 223
            |.:.|....:.|:...:.:|...||...||.|.:..:|  ..::||..||.|||.|..|......
Human    87 EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREK--GCVTEVKYQGSCGACWAFSAVGALE 149

  Fly   224 DRFAIQSKGKENVQLSAQNILSCTRRQ---QGCEGGHLDAAWRY-LHKKGVVDENCYPYTQHRDT 284
            .:..::: || .|.|||||::.|:..:   :||.||.:..|::| :..||:..:..|||......
Human   150 AQLKLKT-GK-LVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQK 212

  Fly   285 CKIRHNSRSLRANGCQKPVNVDRDSLYTVGPAYSLNREADIMAE-IFHSGPVQATMRVNR-DFFA 347
            |  :::|: .||..|.|         ||..|   ..|| |::.| :.:.|||...:.... .||.
Human   213 C--QYDSK-YRAATCSK---------YTELP---YGRE-DVLKEAVANKGPVSVGVDARHPSFFL 261

  Fly   348 YSGGVYRETAANRKAPTGFHSVKLVGWGEEHNGEKYWIAANSWGSWWGEHGYFRILRG-SNECGI 411
            |..|||.|.:..:...   |.|.:||:| :.||::||:..||||..:||.||.|:.|. .|.|||
Human   262 YRSGVYYEPSCTQNVN---HGVLVVGYG-DLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGI 322

  Fly   412 EEYVLASWPYV 422
            ..:  .|:|.:
Human   323 ASF--PSYPEI 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..84	CDD:460034
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	78/235 (33%)
CTSS	NP_004070.3	Inhibitor_I29	28..87	CDD:214853	87/271 (32%)
		Peptidase_C1	115..329	CDD:425470	80/239 (33%)