Protein Alignment Swim and CTSL

DIOPT Version :9

• Sequence 1: NP_611652.2
• Gene: Swim / 37537
• FlyBaseID: FBgn0034709
• Length: 431
• Species: Drosophila melanogaster
• Sequence 2: NP_001244900.1
• Gene: CTSL / 1514
• HGNCID: 2537
• Length: 333
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 90/376 - (23%)
• Similarity: 153/376 - (40%)
• Gaps: 83/376 - (22%)

  Fly    79 SFCIGEVDPIISCEHNGVYFSKYNTTWDNCNECRCLEGGSVQCDEDLCLTDDAIVHSVNSIHRLG 143
            :||:|.....::.:|:   .....|.|                        .|:.:.:..::..|
Human     9 AFCLGIASATLTFDHS---LEAQWTKW------------------------KAMHNRLYGMNEEG 46

  Fly   144 WSARKYD------QWWGRKYSEG---LKLRLG-----TKEPTYRVKAMTRLKNPTDG-------- 186
            |....::      :...::|.||   ..:.:.     |.|...:|....:.:.|..|
Human    47 WRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLF 111

  Fly   187 --LPSSFNALDKWSSYISEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSAQNILSCTRR 249
              .|.|.:..:|  .|::.|.:||.||:.|..|.|.....:. .:..|: .:.||.||::.|:..
Human   112 YEAPRSVDWREK--GYVTPVKNQGQCGSCWAFSATGALEGQM-FRKTGR-LISLSEQNLVDCSGP 172

  Fly   250 Q--QGCEGGHLDAAWRYLHKKGVVD-ENCYPYTQHRDTCKIRHNSRSLRANGCQKPVNVDRDSLY 311
            |  :||.||.:|.|::|:...|.:| |..|||....::||  :|.:...||          |:.:
Human   173 QGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCK--YNPKYSVAN----------DTGF 225

  Fly   312 TVGPAYSLNREADIMAEIFHSGPVQATMRVNRD-FFAYSGGVYRETAANRKAPTGFHSVKLVGWG 375
            ...|    .:|..:|..:...||:...:....: |..|..|:|.|...:.:...  |.|.:||:|
Human   226 VDIP----KQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMD--HGVLVVGYG 284

  Fly   376 ---EEHNGEKYWIAANSWGSWWGEHGYFRILRG-SNECGIEEYVLASWPYV 422
               .|.:..|||:..||||..||..||.::.:. .|.|||..  .||:|.|
Human   285 FESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIAS--AASYPTV 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Swim	NP_611652.2	Somatomedin_B	41..83	CDD:279385	2/3 (67%)
		VWC	91..>126	CDD:302663	3/34 (9%)
		Peptidase_C1A_CathepsinB	188..417	CDD:239111	69/236 (29%)
CTSL	NP_001244900.1	Inhibitor_I29	29..87	CDD:214853	9/81 (11%)
		Peptidase_C1	114..332	CDD:395062	71/241 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840