Protein Alignment Vps35 and VPS35B

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_177713.3
• Gene: VPS35B / 843918
• AraportID: AT1G75850
• Length: 790
• Species: Arabidopsis thaliana
• Alignment Length: 802
• Identity: 327/802 - (40%)
• Similarity: 503/802 - (62%)
• Gaps: 48/802 - (5%)

  Fly    19 VRTMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYEL 83
            :||:. |::|::|.|||.|...:..||.|:..||...:.:.||.::.||.|||||.|||:.||:|
plant     1 MRTLA-GVEDEDKWLAEGIAGIQHNAFFMHRALDANNLREVLKYSALMLSELRTSKLSPQKYYDL 64

  Fly    84 YMAVTNELCHLELYLSEKID---KKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILK 145
            ||...::|..||::..::..   ...|||||||::..|:||:|||.|||.||||:.....:.:||
plant    65 YMRAFDQLRQLEIFFKDESRHGLPVVDLYELVQHAGNILPRMYLLCTVGSVYIKSKQAPSKDVLK 129

  Fly   146 DLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDVMVEENEHEGN---VYDAIDFVLTNFAEMNKLW 207
            ||||||||||||:||||||:||.|.:|:.||::   .:::||:   |.||::|||.||.||||||
plant   130 DLVEMCRGVQHPIRGLFLRSYLAQVSRDKLPEI---GSDYEGDANTVMDAVEFVLQNFTEMNKLW 191

  Fly   208 VRMQHQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQ 272
            ||:||||..:.:.::||||.||:.|||.||..|.|:|...||:|:..:||.:|||||:|:|.:||
plant   192 VRIQHQGPGTVREKQEKERNELRDLVGKNLHVLGQIEGVDLEMYKETVLPRVLEQVVNCKDKLAQ 256

  Fly   273 EYLMECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAI 337
            .|||||||||||||:||:||:..|.:|.||...|:.|.::..|::||:.|    ..:|.:.:...
plant   257 YYLMECIIQVFPDEYHLQTLETLLAACTQLMPTVDTKIVLTQLMDRLSNY----AASSPDVLHEF 317

  Fly   338 IPAEVELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQR 402
            :  :||.|...|..:..::.|:::||:...::|.|:||:...:|:|||:||||:|||  |.:::.
plant   318 L--QVEAFAKLSNAIGKVIDTQLEMPIVGAMTLFVSLLTFTLRVHPDRLDYVDQVLG--ACVVKL 378

  Fly   403 MNMNNISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDN 467
            .::..:....::.|.:: ||...::.|::.:|.:.|.|:..:::..|..:.|.:|:.::.:|:..
plant   379 SSVPKLEDARAMKQVVA-LLSAPLEKYSDIVTALTLSNYPRVMDHLDDGTNKVMAMLIIQSIMKT 442

  Fly   468 ETLVPTADQADSLLTIITPLIKD-DDTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPD 531
            ::.:.|||:.:.|..:|..|||| |:||.|.        .|.|:|.|||..|||.||::.::||:
plant   443 DSCISTADKVEVLFELIKGLIKDLDETNAEE--------LDEEDFQEEQNSVARLIHMLDNEEPE 499

  Fly   532 MQYKMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKA----IAEQDENWDKKCQKIVQYCH 592
            ...|::...|:||..||.:||...:|||||:|.:|..:.::    ||.:|....:   ||.|..:
plant   500 EMLKIICVVRRHLMTGGPRRLPFTVPPLVFSAVRLVRQLESQGGDIAGEDSATPR---KIFQILN 561

  Fly   593 STISALAKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITL 657
            .||..|......:||||||||.|....:   .:.|.|||||.||||.|||:||:|||||:.||.|
plant   562 QTIEVLTSVPCPELALRLYLQCAEAASD---CDLEPVAYEFFTQAFMLYEEEIADSKAQVTAIHL 623

  Fly   658 IMSTFEQMSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGKQNGEEMRDEKRTLD 722
            |:.|.::::.||.||.:.|.......:::|||||||||.|.||:.|||....:|  ::|.:|.|.
plant   624 IVGTLQRINVFGVENRDTLTHKATGYSARLLKKPDQCRAVYACSHLFWVDDPDG--IKDGERVLL 686

  Fly   723 CLKKGARI-------ASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPN 780
            ||::..||       ||....:...|.|:||:||.|:::||:||..||.:.:..||..:|.|:.:
plant   687 CLRRALRIANAAQQMASATRGSSGPVTLFVEILNKYIYFFEKGNPHITPSDIQSLIELINNEMQS 751

  Fly   781 LEPSEETKQIESHYKNTLAHIR 802
             :....|...:..:.:||.:|:
plant   752 -DNGNTTIHSDPFFTSTLRYIK 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	316/761 (42%)
VPS35B	NP_177713.3	Vps35	13..747	CDD:427414	316/761 (42%)