DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps35 and VPS35A

DIOPT Version :9

Sequence 1:	NP_726175.3	Gene:	Vps35 / 37536	FlyBaseID:	FBgn0034708	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_179370.2	Gene:	VPS35A / 816289	AraportID:	AT2G17790	Length:	787	Species:	Arabidopsis thaliana

Alignment Length:	797	Identity:	334/797 - (41%)
Similarity:	485/797 - (60%)	Gaps:	57/797 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYMAVT 88
            :|.:|:||.||......::.||.|...:|...:.|:||.::.||.|||||.|||..||:|||...
plant     4 DGSEDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMRAF 68

  Fly    89 NELCHLELYLSEKIDK---KTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDLVEM 150
            :||..||::..|:..:   ..:||||||::..|:||||||.|.|.||||......:.||||||||
plant    69 DELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEILKDLVEM 133

  Fly   151 CRGVQHPLRGLFLRNYLLQCTRNILPDVMVEENEHEGN---VYDAIDFVLTNFAEMNKLWVRMQH 212
            |||:||||||||||:||.|.:|:.|||:   .:|:||:   |.||::|||.||.|||||||||||
plant   134 CRGIQHPLRGLFLRSYLAQISRDKLPDI---GSEYEGDADTVIDAVEFVLLNFTEMNKLWVRMQH 195

  Fly   213 QGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLME 277
            ||.:.||.||||||.||:.|||.||..|||||...|::|:..:||.:|||:|:|||.|||.||::
plant   196 QGPAREKERREKERGELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQIVNCRDEIAQYYLID 260

  Fly   278 CIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDA-IIP-- 339
            |||||||||:||:|||..|.:|.||:..|::..::..|:|||:.|         .|::| ::|
plant   261 CIIQVFPDEYHLQTLDVLLGACPQLQASVDIMTVLSRLMERLSNY---------AALNAEVLPYF 316

  Fly   340 AEVELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMN 404
            .:||.|...:..:..:::.:.|||:...::|..:||.....|:|||:||.|:|||:..:.|....
plant   317 LQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLDYADQVLGSCVKQLSGKG 381

  Fly   405 MNNISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNET 469
            ..:.:.   ..:||..||...::.||:.:|.::|.|:..::|..|..:::.:|..:|.:|:.|.|
plant   382 KIDDTR---ATKELVSLLSAPLEKYNDVVTALKLTNYPLVVEYLDTETKRIMATVIVRSIMKNNT 443

  Fly   470 LVPTADQADSLLTIITPLIKDDDTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQY 534
            |:.||::.::|..:|..:|.|.|  :..|...     |.::|.|||..||..||::.:|:|:..:
plant   444 LITTAEKVEALFELIKGIINDLD--EPQGLEV-----DEDDFQEEQNSVALLIHMLYNDDPEEMF 501

  Fly   535 KMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQ----KIVQYCHSTI 595
            |::...:||...||.:|||..:||||.:..:|..:..  .|.|..:.|:..    ||.|:.:..|
plant   502 KIVNVLKKHFLTGGPKRLKFTIPPLVVSTLKLIRRLP--VEGDNPFGKEASVTATKIFQFLNQII 564

  Fly   596 SALAKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMS 660
            .||......|||.|||||.|....:   .:.|.:||||.|||:.|||:||||||||:.|:.||:.
plant   565 EALPNVPSPDLAFRLYLQCAEAADK---CDEEPIAYEFFTQAYILYEEEISDSKAQVTALQLIIG 626

  Fly   661 TFEQMSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGKQNGEEMRDEKRTLDCLK 725
            |.::|..||.||.:.|.......|:||||||||||.|.||:.|||  .::.|.::|.:|.|.|||
plant   627 TLQRMQVFGVENRDTLTHKATGYAAKLLKKPDQCRAVYACSHLFW--LEDRETIQDGERVLLCLK 689

  Fly   726 KGARIASQCL--------DTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKV-NEELPNL 781
            :..:||:...        .|| .|.|::|:||.||:::|:|...|||..:..||..: |||....
plant   690 RALKIANSAQQVANTARGSTG-SVTLFIEILNKYLYFYEKGVPQITVESVESLIKLIKNEESMPS 753

  Fly   782 EPSEETKQIESHYKNTL 798
            :||     .||.:..||
plant   754 DPS-----AESFFATTL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..777	CDD:281615	322/766 (42%)
VPS35A	NP_179370.2	Vps35	12..748	CDD:281615	321/765 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	557	1.000	Domainoid score	I48
eggNOG	1	0.900	-	-		E1_KOG1107
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	574	1.000	Inparanoid score	I239
OMA	1	1.010	-	-		QHG54026
OrthoDB	1	1.010	-	-		D316875at2759
OrthoFinder	1	1.000	-	-		FOG0003201
OrthoInspector	1	1.000	-	-		otm3146
orthoMCL	1	0.900	-	-		OOG6_101945
Panther	1	1.100	-	-	O	PTHR11099
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2604
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840