DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps35 and Vps35

DIOPT Version :9

Sequence 1:	NP_726175.3	Gene:	Vps35 / 37536	FlyBaseID:	FBgn0034708	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_075373.1	Gene:	Vps35 / 65114	MGIID:	1890467	Length:	796	Species:	Mus musculus

Alignment Length:	809	Identity:	494/809 - (61%)
Similarity:	635/809 - (78%)	Gaps:	24/809 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYM 85
            |..:..|:|||||.|||...:.|:|||...|||.:::|:||.||.||||||||:|||||||||||
Mouse     4 TQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYM 68

  Fly    86 AVTNELCHLELYLSE---KIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDL 147
            |:::||.:||:||::   |..|..||||||||:..|:||||||||||:||:|:.|..::.|||||
Mouse    69 AISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDL 133

  Fly   148 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDV-MVEENEHEGNVYDAIDFVLTNFAEMNKLWVRMQ 211
            ||||||||||||||||||||||||||||||. ...:.|..|::.|::||||.|||||||||||||
Mouse   134 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQ 198

  Fly   212 HQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLM 276
            |||||.::.:||:||:||:||||||||||||||...:|.|::::|.|||||||:||||:||||||
Mouse   199 HQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLM 263

  Fly   277 ECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAIIPAE 341
            |||||||||||||:||:|||::||:|...||||||||:||:|||.:..|.....       ||||
Mouse   264 ECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPG-------IPAE 321

  Fly   342 VELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMNMN 406
            ::||::||.|||.::|:|.|||.||.:||||:|::||.|.||||||||||||.||.:|..::|:.
Mouse   322 IKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLE 386

  Fly   407 NISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNETLV 471
            :|:...:|::||:|||:|.:|.|||.||:::|::|.||.|.|||.||||::.|::.|:||..|.:
Mouse   387 HIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEI 451

  Fly   472 PTADQADSLLTIITPLIKDD-DTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQYK 535
            .:.||.||::.:::.||:|. |...|:        ||.|:||:||.:|.|||||:|||:||.||.
Mouse   452 VSQDQVDSIMNLVSTLIQDQPDQPVED--------PDPEDFADEQSLVGRFIHLLRSDDPDQQYL 508

  Fly   536 MLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYCHSTISALAK 600
            :|.|||||.|.||.||::..|||||||||||||:||..::.|:.|:||||||..:.|.|||||.|
Mouse   509 ILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSQMDDKWEKKCQKIFSFAHQTISALIK 573

  Fly   601 ADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMSTFEQM 665
            |:||:|.|||:|||||..||||:.||||||||||:|||||||||||||||||||||||:.|||:|
Mouse   574 AELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERM 638

  Fly   666 SCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGK---QNGEEMRDEKRTLDCLKKG 727
            .||.|||.|||||.||||||||||||||.|.|..||.|||||:   :||||:...||.::||||.
Mouse   639 KCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKA 703

  Fly   728 ARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLEPSEETKQIES 792
            .:||:||:|..:||||::|:||.|::::|:.|..:|:.:|||||.|:.|:|||||.||||:||..
Mouse   704 LKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINK 768

  Fly   793 HYKNTLAHIRSRMESNDSSLEVSFAGITL 821
            |:.|||.|:|||.||.:|...: :.|:.|
Mouse   769 HFHNTLEHLRSRRESPESEGPI-YEGLIL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..777	CDD:281615	464/752 (62%)
Vps35	NP_075373.1	Vps35	15..752	CDD:397615	459/744 (62%)
		Interaction with SNX3. /evidence=ECO:0000250\|UniProtKB:Q96QK1	25..44		8/18 (44%)
		Interaction with SNX3. /evidence=ECO:0000250\|UniProtKB:Q96QK1	205..215		6/9 (67%)
		Interaction with SLC11A2. /evidence=ECO:0000250\|UniProtKB:Q96QK1	438..796		217/361 (60%)
		Interaction with IGF2R cytoplasmic domain. /evidence=ECO:0000250\|UniProtKB:Q96QK1	500..693		140/195 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..796		11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850397
Domainoid	1	1.000	931	1.000	Domainoid score	I38
eggNOG	1	0.900	-	-		E1_KOG1107
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6221
Inparanoid	1	1.050	985	1.000	Inparanoid score	I312
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54026
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003201
OrthoInspector	1	1.000	-	-		oto93955
orthoMCL	1	0.900	-	-		OOG6_101945
Panther	1	1.100	-	-	LDO	PTHR11099
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1652
SonicParanoid	1	1.000	-	-		X2604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790