DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps35 and vps35

DIOPT Version :9

Sequence 1:	NP_726175.3	Gene:	Vps35 / 37536	FlyBaseID:	FBgn0034708	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	XP_012816642.1	Gene:	vps35 / 549980	XenbaseID:	XB-GENE-941152	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	810	Identity:	487/810 - (60%)
Similarity:	634/810 - (78%)	Gaps:	26/810 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYM 85
            |..:..|:|||||.||:...:.|:|||...|||.:::|:||.||.||||||||:|||||||||||
Frog     4 TQQSPQDEQEKLLDEAVQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYM 68

  Fly    86 AVTNELCHLELYLSE---KIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDL 147
            |:::||.:||:||::   |..|..||||||||:..|:||||||||||:||:|:....::.||||:
Frog    69 AISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFSQSRKDILKDM 133

  Fly   148 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDVMVEENEH-EGNVYDAIDFVLTNFAEMNKLWVRMQ 211
            ||||||||||||||||||||||||||||||...:.||. .|::.|::||||.|||||||||||||
Frog   134 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEQTNEEVTGDISDSMDFVLLNFAEMNKLWVRMQ 198

  Fly   212 HQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLM 276
            |||||.:|.:||:||:||:||||||||||||||...:|.|::::|||||||||:||||:||||||
Frog   199 HQGHSRDKEKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLPGILEQVVNCRDALAQEYLM 263

  Fly   277 ECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAIIPAE 341
            |||||||||||||:||:|||::||:|...||||||||:||:|||.:..|.....       |||:
Frog   264 ECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPG-------IPAD 321

  Fly   342 VELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMNMN 406
            ::||::||.|||.::|:|.|||.||.:||||:|::||.|.||||||||||||.||.:|..::|:.
Frog   322 IKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLE 386

  Fly   407 NISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNETLV 471
            :|:...:|::||:|||:|.:|.|||.||:::|::|.||.|.|||.||||::.|::.|.|:..|.:
Frog   387 HIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNALEYNTEI 451

  Fly   472 PTADQADSLLTIITPLIKD--DDTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQY 534
            .:.:|.|:::.:::.||:|  |...:|         ||.|:||:|||:|.|||||:|||:||.||
Frog   452 GSQEQVDAIMNLVSTLIQDQPDQPAEE---------PDPEDFADEQGLVGRFIHLLRSDDPDQQY 507

  Fly   535 KMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYCHSTISALA 599
            .:|.|||||.|.||.||::..|||||||||:|||:||..|:.|:.|:||||||..:.|.|||||.
Frog   508 LILNTARKHFGAGGNQRIRFTLPPLVFAAYKLAFRYKENAKVDDKWEKKCQKIFSFAHQTISALI 572

  Fly   600 KADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMSTFEQ 664
            ||:||:|.|||:|||||..||||:.||||||||||:|||||||||||||||||||||||:.|||:
Frog   573 KAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFEK 637

  Fly   665 MSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGK---QNGEEMRDEKRTLDCLKK 726
            |.||.|||.|||||..|||||||||||||||.|...|.|||||:   :||||:...||.::||||
Frog   638 MKCFSEENHEPLRTQSALAASKLLKKPDQCRAVSISAHLFWSGRNTDKNGEEIHSGKRVMECLKK 702

  Fly   727 GARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLEPSEETKQIE 791
            ..:||:||:|..:||||::|:||.|::::|:.|..:||.:|||||.|:.|:||||:.:|||.||.
Frog   703 ALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDGVTVQVLNQLIQKIREDLPNLDATEETDQIS 767

  Fly   792 SHYKNTLAHIRSRMESNDSSLEVSFAGITL 821
            :|:||||.|:|.|.:|.:....: :.|:.|
Frog   768 THFKNTLEHLRLRKDSPEGDGPI-YEGLVL 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..777	CDD:281615	461/753 (61%)
vps35	XP_012816642.1	Vps35	15..752	CDD:367586	461/752 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	918	1.000	Domainoid score	I49
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	975	1.000	Inparanoid score	I318
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115466at33208
OrthoFinder	1	1.000	-	-		FOG0003201
OrthoInspector	1	1.000	-	-		oto104178
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2604
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060