Protein Alignment Vps35 and Vps35

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_001099188.2
• Gene: Vps35 / 25479
• RGDID: 1589784
• Length: 796
• Species: Rattus norvegicus
• Alignment Length: 809
• Identity: 492/809 - (60%)
• Similarity: 635/809 - (78%)
• Gaps: 24/809 - (2%)

  Fly    21 TMPNGLDDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYM 85
            |..:..|:|||||.|||...:.|:|||...|||.:::|:||.||.||||||||:|||||||||||
  Rat     4 TQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYM 68

  Fly    86 AVTNELCHLELYLSE---KIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDL 147
            |:::||.:||:||::   |..|..||||||||:..|:||||||||||:||:|:.|..::.|||||
  Rat    69 AISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDL 133

  Fly   148 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDV-MVEENEHEGNVYDAIDFVLTNFAEMNKLWVRMQ 211
            ||||||||||||||||||||||||||||||. ...:.|..|::.|::||||.|||||||||||||
  Rat   134 VEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQ 198

  Fly   212 HQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAIAQEYLM 276
            |||||.::.:||:||:||:||||||||||||||...:|.|::::|.|||||||:||||:||||||
  Rat   199 HQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLM 263

  Fly   277 ECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSGNAIDAIIPAE 341
            |||||||||||||:||:|||::||:|...||||||||:||:|||.:..|.....       ||||
  Rat   264 ECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPG-------IPAE 321

  Fly   342 VELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTTAQILQRMNMN 406
            ::||::||.|||.::|:|.|||.||.:||||:|::||.|.||||||||||||.||.:|..::|:.
  Rat   322 IKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLE 386

  Fly   407 NISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLVMNILDNETLV 471
            :|:...:|::||:|||:|.:|.|||.||:::|::|.||.|.|||.||||::.|::.|:||..|.:
  Rat   387 HIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEI 451

  Fly   472 PTADQADSLLTIITPLIKDD-DTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMRSDEPDMQYK 535
            .:.||.||::.:::.||:|. |...|:        ||.|:||:||.:|.|||||:||::||.||.
  Rat   452 VSQDQVDSIMNLVSTLIQDQPDQPVED--------PDPEDFADEQSLVGRFIHLLRSEDPDQQYL 508

  Fly   536 MLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYCHSTISALAK 600
            :|.|||||.|.||.||::..|||||||||||||:||..::.|:.|:||||||..:.|.|||||.|
  Rat   509 ILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSQMDDKWEKKCQKIFSFAHQTISALIK 573

  Fly   601 ADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMSTFEQM 665
            |:||:|.|||:|||||..||||:.||||||||||:|||||||||:|||||||||||||:.|||:|
  Rat   574 AELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDELSDSKAQLAAITLIIGTFERM 638

  Fly   666 SCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSGK---QNGEEMRDEKRTLDCLKKG 727
            .||.|||.|||||.||||||||||||||.|.|..||.|||||:   :||||:...||.::||||.
  Rat   639 KCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKA 703

  Fly   728 ARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLEPSEETKQIES 792
            .:||:||:|..:||||::|:||.|::::|:.|..:|:.:|||||.|:.|:|||||.||||:||..
  Rat   704 LKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINK 768

  Fly   793 HYKNTLAHIRSRMESNDSSLEVSFAGITL 821
            |:.|||.|:|||.||.:|...: :.|:.|
  Rat   769 HFHNTLEHLRSRRESPESEGPI-YEGLIL 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	462/751 (62%)
Vps35	NP_001099188.2	Vps35	15..752	CDD:427414	457/744 (61%)