Protein Alignment Vps35 and vps35

DIOPT Version :10

• Sequence 1: NP_726175.3
• Gene: Vps35 / 37536
• FlyBaseID: FBgn0034708
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_588260.2
• Gene: vps35 / 2539462
• PomBaseID: SPCC777.13
• Length: 836
• Species: Schizosaccharomyces pombe
• Alignment Length: 861
• Identity: 273/861 - (31%)
• Similarity: 446/861 - (51%)
• Gaps: 113/861 - (13%)

  Fly    24 NGL----DDQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELY 84
            ||:    ::..:.|.|::.:.::.:..|...|...|::|:.:..|..|.|:|.|.|:||.|||||
pombe     2 NGINTANEEITRSLEESLNICKQSSRLMQRNLQTGRLMDAFRNCSISLVEMRNSALTPKQYYELY 66

  Fly    85 MAVTNEL-----CHLELYLSEKIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSIL 144
            |.....|     ..||.:|: ......||||||||:.:|||||||:||||..|::....|.|.|:
pombe    67 MFNMESLRLLGGTLLETHLN-GTHNLMDLYELVQYAGSIVPRLYLMITVGSAYLETPNALVREIM 130

  Fly   145 KDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDVMVEENEHE----GNVYDAIDFVLTNFAEMNK 205
            .||::|||||||||||||||:|||..||..||  :..|:|.:    |.|.|::.|::.||.||||
pombe   131 NDLLDMCRGVQHPLRGLFLRHYLLTQTRKGLP--LGSEDEEDASRKGTVLDSVKFLVINFTEMNK 193

  Fly   206 LWVRMQHQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSCRDAI 270
            ||||:||.|...|.::|.:||.|||:|||.|||||||| :..::.|:..:||.|:||::.|||::
pombe   194 LWVRIQHLGPIKEFSKRTQERNELKVLVGLNLVRLSQL-NLDIDTYRDHVLPAIIEQIIECRDSL 257

  Fly   271 AQEYLMECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQR------SGKT 329
            |||||:|.|.|.|.|..||:|||.:..:..:|...|||..::::::.||..|.||      |.:.
pombe   258 AQEYLVEVICQAFSDNMHLQTLDTYFGTVIKLSPSVNVTQLVVAMLNRLTDYVQREYESDSSNED 322

  Fly   330 SGNAI-----------------------DAIIPAEVELFEVFSVQVANIVQTRMDMPLEDTISLQ 371
            ....:                       |.:||.|..:.||....|..::|:|..:||:..:|:.
pombe   323 ESETVTEKLGDIKINEEVQQKDEQECPGDKVIPPEYAIQEVLWSHVVEVIQSRSGLPLDCIVSIL 387

  Fly   372 VALLSLAQKVYPDRVDYVDKVLG-TTAQILQRMNMNNISHLLSVNQELSRLLRICIDFYNNALTI 435
            .::|:...:.||.:..|.|:|.. ....|:.:.::.:..|...:.:.|..:|.:.:.::.:....
pombe   388 SSILNFFLRCYPYKPQYADRVFQYINEHIINQPSLRSALHERPLQKSLCAILLLPLTYFPSFSYC 452

  Fly   436 IQLQNFCPLLEKFDYTSRKSLALYLVMNILDNETLVPTADQADSLLTIITPLIKDDDTNKENGAA 500
            ::||||.|:....|...|..:|..:|..|::....:....:|..||..::.:|
pombe   453 LELQNFLPVFNAQDPNLRYDIARMIVQKIIEKGHSLSELTEAQELLGFVSVII------------ 505

  Fly   501 AGNTTPDAEEFAEEQGV--------VARFIHLMRSDEPDMQYKMLQTARKHLGNGGGQRLKHVLP 557
                        |::||        ||..:|.:.:|:|.:|.::|::. |......|:.:|::||
pombe   506 ------------EKKGVDSLDDLQNVALMVHYLNNDDPQIQIEILRSL-KDTFIKAGENVKYLLP 557

  Fly   558 PLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYCHSTISALAK-ADLADLALRLYLQGALVIGEI 621
            .:|.....||..::.....|  |.:|.:.:.::.::.|:.|.| .|..:|.|.|||..|.:..:
pombe   558 VVVNRCIFLARNFRIFKCMD--WAEKVRLLWEFVNTCINVLYKNGDSLELCLALYLSAAEMADQ- 619

  Fly   622 GYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAITLIMSTFEQMSCFGEENAEPLRTNCALAASK 686
              .|:...||||.|||||:||:.:.||:.|...:.:|:...::...|..::.:.|.|.|.|.|||
pombe   620 --ENYPDFAYEFFTQAFSIYEESVLDSELQYQQLLMIIGKLQKTRNFSVDDYDTLITKCTLYASK 682

  Fly   687 LLKKPDQCRGVVACAALFWSGKQNGEEMR---DEKRTLDCLKKGARIASQCLDTGVQVQLYVELL 748
            ||||||||.|:...:.|:|. ..:||:.|   |.||.|:||:|..:||..|:|....::|::.:|
pombe   683 LLKKPDQCCGIYLASHLWWQ-VASGEDSRPFQDPKRVLECLQKSLKIADACMDQLTSLKLFINIL 746

  Fly   749 NHYLFYFERGNSLITVAMLNQLIAKVNEELPNL-----------EPSEETKQI------------ 790
            ..|.:|:::....|....::.||....:.:.::           :|......|
pombe   747 ERYFYYYDQHCESIIAKHISGLIDLTEQNMRSILISSPADLIASDPRAYASSIWEVANVSVIDSL 811

  Fly   791 ESHYKNTLAHIRSRME 806
            ::|.:...|:...|.|
pombe   812 KNHLERATAYAEKRSE 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..776	CDD:427414	265/794 (33%)
vps35	NP_588260.2	Vps35	14..774	CDD:427414	265/794 (33%)