DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps35 and vps-35

DIOPT Version :9

Sequence 1:	NP_726175.3	Gene:	Vps35 / 37536	FlyBaseID:	FBgn0034708	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_495180.2	Gene:	vps-35 / 174000	WormBaseID:	WBGene00006933	Length:	821	Species:	Caenorhabditis elegans

Alignment Length:	818	Identity:	357/818 - (43%)
Similarity:	530/818 - (64%)	Gaps:	44/818 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DQEKLLAEAIGLARKQAFQMNHFLDKERMLDSLKCASTMLGELRTSVLSPKSYYELYMAVTNELC 92
            ||||.|.::|.:.:.::|:|...|||.:.:|:||.|..||.|:||:.||||.||.|||...:||.
Worm    10 DQEKFLDQSIRVVKAESFEMKRCLDKGKTMDALKHALQMLNEMRTAELSPKFYYRLYMDSMHELQ 74

  Fly    93 HLELYL----SEKIDKKTDLYELVQYSHTIVPRLYLLITVGIVYIKNDPTLKRSILKDLVEMCRG 153
            .||:.|    :::..|..:|||.|||:..|:||||||:|:|.|:||.....::.|||||||||||
Worm    75 CLEVNLVQEYAQEPAKLGNLYECVQYASAIIPRLYLLVTIGGVFIKCGLGSRKEILKDLVEMCRG 139

  Fly   154 VQHPLRGLFLRNYLLQCTRNILPD------VMVEENEH-----------EGNVYDAIDFVLTNFA 201
            ||||||||||||||:||||::|||      ::|..|::           :|.|.|.|||||.|||
Worm   140 VQHPLRGLFLRNYLMQCTRSVLPDFPETEEMLVAHNDNLSKGTPKLKPRDGTVDDTIDFVLINFA 204

  Fly   202 EMNKLWVRMQHQGHSSEKTRREKEREELKILVGTNLVRLSQLESATLEIYQRLILPGILEQVVSC 266
            |||||||||||||.|.||.:|||:|.||:||||||||||:|||:.|.|:|.:.:||.||||:|||
Worm   205 EMNKLWVRMQHQGPSKEKEKREKDRMELRILVGTNLVRLAQLEALTEEMYVKDVLPSILEQIVSC 269

  Fly   267 RDAIAQEYLMECIIQVFPDEFHLKTLDPFLKSCAQLETGVNVKNIIISLIERLAAYNQRSGKTSG 331
            ||.|:|||||||:||||.|:|||.||..||.:|.||:..||:|.::|:|::|||.|.     ||.
Worm   270 RDPISQEYLMECVIQVFADDFHLATLTEFLNACGQLQQDVNIKILLIALVDRLALYT-----TSY 329

  Fly   332 NAIDAIIPAEVELFEVFSVQVANIVQTRMDMPLEDTISLQVALLSLAQKVYPDRVDYVDKVLGTT 396
            |. ....|.:::|||:||.|...:::.|.||||:|.::|.|:|:|||.|.||||.||.:......
Worm   330 NE-GQPAPTKMQLFEIFSEQATTLIKNRPDMPLDDIVALHVSLVSLAVKCYPDRQDYANMTFQGL 393

  Fly   397 AQILQRMNMNNISHLLSVNQELSRLLRICIDFYNNALTIIQLQNFCPLLEKFDYTSRKSLALYLV 461
            .|:::...:.:|.....|.:||::||.|.||.|.|.|.:.||..:..::..|||..:.::|.|::
Worm   394 RQVIEEKGVTDIEAFGKVGRELTKLLNIPIDEYKNVLRLSQLPEYIKVMNYFDYRGQCNIASYMI 458

  Fly   462 MNILDNETLVPTADQADSLLTIITPLIKDDDTNKENGAAAGNTTPDAEEFAEEQGVVARFIHLMR 526
            .|:|:.||:....|..||..::|:.|:||.:....:       :.:.||||:||.:|||.:||:|
Worm   459 QNMLEEETVFRNQDDVDSAFSLISSLLKDQEKQSSD-------SHETEEFADEQNLVARLLHLIR 516

  Fly   527 SDEPDMQYKMLQTARKHLGNGGGQRLKHVLPPLVFAAYQLAFKYKAIAEQDENWDKKCQKIVQYC 591
            :|:.|.|:.:|.:|||.||.||..||::.|||::|..|:|..::..:.::|:.||.|.:|:....
Worm   517 ADDVDSQFLLLNSARKTLGEGGRHRLRYTLPPIIFELYRLVLQFSDMKDEDDKWDAKIRKMFVCA 581

  Fly   592 HSTISAL-AKADLADLALRLYLQGALVIGEIGYTNHETVAYEFMTQAFSLYEDEISDSKAQLAAI 655
            ..||.|| :.|:||:|.::|||.||:....:.:.::.||.|||:::|.|:.||::.||:.::..:
Worm   582 MGTIGALVSTAELAELPMKLYLNGAITADRVPFEDNHTVVYEFVSKALSILEDDVVDSRDRVRCL 646

  Fly   656 TLIMSTFEQMSCFGEENAEPLRTNCALAASKLLKKPDQCRGVVACAALFWSG---KQNGEEMRDE 717
            .|.:.|..:.:...|||.:||.....|||:|:.|||||.|.:|..|||:|.|   :.|||:|::.
Worm   647 HLTVGTLLKTTHLPEENWQPLANQTVLAAAKMFKKPDQVRSLVTVAALYWHGQTLETNGEKMKNG 711

  Fly   718 KRTLDCLKKGARIASQCLDTGVQVQLYVELLNHYLFYFERGNSLITVAMLNQLIAKVNEELPNLE 782
            |:.:|.|:|.|:||.:||:..||.||:::||:.|.:|:|...|.:.|..:.:|||:..:....|:
Worm   712 KKVVDILRKAAKIARECLEPLVQQQLFIQLLSAYTYYYEDNCSEVNVDHIEELIARTQDNAVQLD 776

  Fly   783 PSEETKQIESHYKNTLAHIRSRMESNDSSLEVSFAGIT 820
            .|.|...:|......:..::.      :.|:|:.|..|
Worm   777 VSAEADSLEKQLGEAIRRLQL------AKLDVAAAQAT 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps35	NP_726175.3	Vps35	32..777	CDD:281615	345/769 (45%)
vps-35	NP_495180.2	Vps35	14..771	CDD:281615	345/769 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167546
Domainoid	1	1.000	656	1.000	Domainoid score	I68
eggNOG	1	0.900	-	-		E1_KOG1107
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6221
Inparanoid	1	1.050	673	1.000	Inparanoid score	I376
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54026
OrthoDB	1	1.010	-	-		D115466at33208
OrthoFinder	1	1.000	-	-		FOG0003201
OrthoInspector	1	1.000	-	-		oto17371
orthoMCL	1	0.900	-	-		OOG6_101945
Panther	1	1.100	-	-	LDO	PTHR11099
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1652
SonicParanoid	1	1.000	-	-		X2604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800