Protein Alignment MED16 and Med16

DIOPT Version :10

• Sequence 1: NP_611650.2
• Gene: MED16 / 37535
• FlyBaseID: FBgn0034707
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_006240923.1
• Gene: Med16 / 299607
• RGDID: 1308001
• Length: 893
• Species: Rattus norvegicus
• Alignment Length: 934
• Identity: 261/934 - (27%)
• Similarity: 414/934 - (44%)
• Gaps: 200/934 - (21%)

  Fly     1 MTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSA-LQSAIFPASHGGDAGDGSLPGAGLAVG 64
            |.:.|..|.::::|.:..|...:.|:.|.||::||:. |::.....:|
  Rat    38 MDLAYVCEWEKWAKSTYCPSLPLACAWSCRNLIAFTTDLRNDDQDLTH----------------- 85

  Fly    65 ASNSHVYVCDIVTPWEYYKVCSSKS-LISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQ 128
                .:::.|...|||.:.|.|..| .|:.|:|..:|.:||.....|:::.|...:...|.|...
  Rat    86 ----MIHILDTEHPWEVHSVSSGHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESS 146

  Fly   129 YYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSS 193
            ..:.|..:.|:...:..||..:..:..|...:.:.|||.||:.. |:|:.|||...||.:.:|.|
  Rat   147 VGSQVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFS-PSLTLFGGKPMEGWIAVTVS 210

  Fly   194 GLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQ 258
            ||:....|.            |:.:|:..|.:|..:   |..:....:..:..|.:.:|.:.|..
  Rat   211 GLVTVSLLK------------PSGQVLTSTESLCRL---RGRVALADIAFTGGGNIVVAAADGSS 260

  Fly   259 QQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLG-PLDGRR------ISHLKW-TRIANEDVI 315
            ...|:.:||.:|:     :.:...|.:|...|:|:. ..|..|      |:|||: .|..:|.|:
  Rat   261 ASPVKFYKVCVSV-----VSEKCRIDTEILPSLFMRCTTDPNRKDRFPAITHLKFLARDMSEQVL 320

  Fly   316 FIAYACPDGAGSQLEQWTLTRRHQSVHALLQGGGGANNKPNEFVQSESWEQVGKVQLNASLAD-- 378
            ..|   .....|.:|.|:|.:....|:.:.|     ...|   |..:....:.|.::.::..|
  Rat   321 LCA---SSQTSSLVECWSLRKEGLPVNNIFQ-----QISP---VVGDKQPMILKWRILSATNDLD 374

  Fly   379 -----------ISVTRLSVSTPDSCQVYAIL------QDNSVQVLEPNSM-----------KQLN 415
                       ||:|...:......|.|..|      ||.||.::...|:           :.|:
  Rat   375 RVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFQDGSVHMVHRLSLQTMAVFYSSAPRSLD 439

  Fly   416 HTQFDRLSDASGAVKFVSGDLTPSSQILLIFDSHAQL----------YAMQAPLPKQGGSGLLLL 470
            .....|......||.|.:..|:.:|..|:..|:|.:|          :|::..|..|  ..|.||
  Rat   440 EPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSLGHALEPKLALQ--HLLFLL 502

  Fly   471 EYCIVTGCDASDVLL-LNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRM------Q 528
            |||:|||.|..|:|| :..|.:::|||:|.:.:|||...::.......||:|:::|::      :
  Rat   503 EYCMVTGYDWWDILLHVQPGMVQSLVERLHEEYTRQKPALQQVLSTRILAMKASLCKLSPCTMAR 567

  Fly   529 QQEFDNLIILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDV--DTVMLNLDAKDFTVE 591
            ..::...:.|.||::|.||||||..|...||.|.|.|| ::...|.||  |.||:||..::|.::
  Rat   568 VCDYHTKLFLMAITSTLKSLLRPHFLNTPDKSPGDRLA-EICAKITDVDIDKVMINLKTEEFVLD 631

  Fly   592 PVMLQSLQQLIQWVTDLALNMLHRLPEE----------------VMK-------TKLSGKRPSYD 633
            ...||:||||:|||.|..|.:|..||.:                |:|       ||.|..||.:.
  Rat   632 MNTLQALQQLLQWVGDFVLYLLVSLPNQGAEHSSGLPDSASHGPVLKSHVSPDFTKGSALRPGHS 696

  Fly   634 ISRDIVAISSLRELLVMIRIWGLLNTQCLPVYTKTMDNIDVLVILFRLLTRL-----AQNPA-EP 692
            ..||..::..||||:|:|||||||...||||||.|.|..|.:.:||||||:|     .:.|| ||
  Rat   697 FLRDGASLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEP 761

  Fly   693 DEMLLDECSLLSKQLLIPQ---------------------------PTKFNPTTLLSAQGFAAVK 730
            ||.|:|||.||..|||:|.                           ||..:.|::|...|....
  Rat   762 DEGLVDECCLLPSQLLVPSLDWLPASDGLVSRLQPKQPLRLRFGRAPTLPSSTSILQLDGLTRA- 825

  Fly   731 SGQLQFTSMEEPTCLQDMETEEVVFASSVKDGVSNLQLGARPS-HIRRCARCGFVFVNNASKVAK 794
            .||.:.                        |.:..|.|||.|: ..:.|.|||.|.:..:..  |
  Rat   826 PGQPKI------------------------DHLRRLHLGAYPTEECKACTRCGCVTMLKSPN--K 864

  Fly   795 TSALKAWFSKWL-HCHCGGFWKQV 817
            |:|:|.|..:|: :|.|||.|::|
  Rat   865 TTAVKQWEQRWIKNCLCGGLWRRV 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED16	NP_611650.2	Med16	128..816	CDD:371639	230/802 (29%)
Med16	XP_006240923.1	WD40 repeat	62..104	CDD:293791	13/62 (21%)
		WD40	95..134	CDD:197651	13/38 (34%)
		WD40 repeat	109..149	CDD:293791	10/39 (26%)
		Med16	144..886	CDD:371639	229/803 (29%)
		WD40 repeat	187..229	CDD:293791	15/54 (28%)